Phytochemicals in cancer treatment: From preclinical studies to clinical practice

AS Choudhari, PC Mandave, M Deshpande… - Frontiers in …, 2020 - frontiersin.org
Cancer is a severe health problem that continues to be a leading cause of death worldwide.
Increasing knowledge of the molecular mechanisms underlying cancer progression has led …

Is target-based drug discovery efficient? Discovery and “off-target” mechanisms of all drugs

A Sadri - Journal of medicinal chemistry, 2023 - ACS Publications
Target-based drug discovery is the dominant paradigm of drug discovery; however, a
comprehensive evaluation of its real-world efficiency is lacking. Here, a manual systematic …

Progress in approved drugs from natural product resources

LUO Zhongwen, YIN Fucheng, W **aobing… - Chinese Journal of …, 2024 - Elsevier
Natural products (NPs) have consistently played a pivotal role in pharmaceutical research,
exerting profound impacts on the treatment of human diseases. A significant proportion of …

Plant derived substances with anti-cancer activity: from folklore to practice

M Fridlender, Y Kapulnik, H Koltai - Frontiers in plant science, 2015 - frontiersin.org
Plants have had an essential role in the folklore of ancient cultures. In addition to the use as
food and spices, plants have also been utilized as medicines for over 5000 years. It is …

A historical overview of natural products in drug discovery

DA Dias, S Urban, U Roessner - Metabolites, 2012 - mdpi.com
Historically, natural products have been used since ancient times and in folklore for the
treatment of many diseases and illnesses. Classical natural product chemistry …

Biologically active isoquinoline alkaloids covering 2014–2018

XF Shang, CJ Yang… - Medicinal research …, 2020 - Wiley Online Library
Isoquinoline alkaloids, an important class of N‐based heterocyclic compounds, have
attracted considerable attention from researchers worldwide since the early 19th century …

Neuroprotective and anti-aging potentials of essential oils from aromatic and medicinal plants

M Ayaz, A Sadiq, M Junaid, F Ullah… - Frontiers in aging …, 2017 - frontiersin.org
The use of essential oils (EOs) and their components is known since long in traditional
medicine and aromatherapy for the management of various diseases, and is further …

[HTML][HTML] A molecular approach in drug development for Alzheimer's disease

S Agatonovic-Kustrin, C Kettle, DW Morton - Biomedicine & …, 2018 - Elsevier
An increase in dementia numbers and global trends in population aging across the world
prompts the need for new medications to treat the complex biological dysfunctions, such as …

[KNJIGA][B] Medicinal natural products: a biosynthetic approach

PM Dewick - 2002 - books.google.com
Medicinal Natural Products, Second Edition is a comprehensive guide providing information
on all classes of natural products in medicine. It builds upon fundamental chemical …

Drug discovery from medicinal plants

MJ Balunas, AD Kinghorn - Life sciences, 2005 - Elsevier
Current research in drug discovery from medicinal plants involves a multifaceted approach
combining botanical, phytochemical, biological, and molecular techniques. Medicinal plant …