Proteasome is a multi-subunit protein degradation machine, which plays a key role in the
maintenance of protein homeostasis and, through degradation of regulatory proteins, in the …

As the central figure of the cellular protein degradation machinery, the proteasome is critical
for cell survival. Having been extensively targeted for inhibition, the constitutive proteasome …

The proteasome is the central component of the main cellular protein degradation pathway.
During the past four decades, the critical function of the proteasome in numerous …

The immunoproteasome (iP) has been proposed to perform specialized roles in MHC class I
antigen presentation, cytokine modulation, and T cell differentiation and has emerged as a …

The nose-horned viper, its nominotypical subspecies Vipera ammodytes ammodytes (Vaa),
in particular, is, medically, one of the most relevant snakes in Europe. The local and …

Vipera berus berus (Vbb) is the most widely distributed and Vipera ammodytes ammodytes
(Vaa) the most venomous viper in Europe. In particular areas of the Old continent their toxic …

Noninvasive monitoring of chymotrypsin-like (ChT-L) activity of proteasomes is of great
significance for the diagnosis and prognosis of various cancers. However, commercially …

The immunoproteasome, a specialized form of proteasome, is mainly expressed in
lymphocytes and monocytes of jawed vertebrates and responsible for the generation of …

Human DNA topoisomerase IIα is a biological nanomachine that regulates the topological
changes of the DNA molecule and is considered a prime target for anticancer drugs. Despite …

Nasopharyngeal carcinoma (NPC) represents a molecularly paradigmatic tumor given the
complex diversity of environmental as well as host dependent factors that are closely …