I. Executive Summary Background The 5 years since the publication of the first International
Consensus Statement on Allergy and Rhinology: Rhinosinusitis (ICAR‐RS) has witnessed …

The Th2 cytokines interleukin 4 (IL‐4) and IL‐13 and the heterodimeric IL‐4 receptor (IL‐4R)
complexes that they interact with play a key role in the pathogenesis of allergic disorders …

Coordinated cell interactions within the esophagus maintain homeostasis, and disruption
can lead to eosinophilic esophagitis (EoE), a chronic inflammatory disease with poorly …

Chronic rhinosinusitis (CRS) is a common clinical syndrome that produces significant
morbidity and costs to our health system. The study of CRS has progressed from an era …

The heterogeneous cellular microenvironment of human airway chronic inflammatory
diseases, including chronic rhinosinusitis (CRS) and asthma, is still poorly understood …

Formation of specialized pro-resolving lipid mediators (SPMs) such as lipoxins or resolvins
usually involves arachidonic acid 5-lipoxygenase (5-LO, ALOX5) and different types of …

During the past years, there has been a global outbreak of allergic diseases, presenting a
considerable medical and socioeconomical burden. A large fraction of allergic diseases is …

Knowledge of chronic rhinosinusitis (CRS) epidemiology may directly impact patient care:
aiding patient identification and establishing accurate diagnosis as well as informing …

Evaluation and effective management of asthma, and in particular severe asthma, remains
at the core of pulmonary practice. Over the last 20–30 years, there has been increasing …

Eosinophilic airway inflammation is one of the cardinal features of allergic airway diseases
such as atopic asthma and allergic rhinitis. These childhood‐onset conditions are mediated …