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YAP/TAZ as master regulators in cancer: modulation, function and therapeutic approaches
S Piccolo, T Panciera, P Contessotto, M Cordenonsi - Nature cancer, 2023 - nature.com
Our understanding of the function of the transcriptional regulators YAP and TAZ (YAP/TAZ)
in cancer is advancing. In this Review, we provide an update on recent progress in YAP/TAZ …
in cancer is advancing. In this Review, we provide an update on recent progress in YAP/TAZ …
[HTML][HTML] Mechanisms and disease consequences of nonalcoholic fatty liver disease
Nonalcoholic fatty liver disease (NAFLD) is the leading chronic liver disease worldwide. Its
more advanced subtype, nonalcoholic steatohepatitis (NASH), connotes progressive liver …
more advanced subtype, nonalcoholic steatohepatitis (NASH), connotes progressive liver …
Tumor organoids: Opportunities and challenges to guide precision medicine
Tumor organoids have been proposed as a model system for precision medicine. The ability
of tumor organoids to retain characteristics of the original tumor makes them unique for …
of tumor organoids to retain characteristics of the original tumor makes them unique for …
Liver regeneration and inflammation: from fundamental science to clinical applications
Liver regeneration is a complex process involving the crosstalk of multiple cell types,
including hepatocytes, hepatic stellate cells, endothelial cells and inflammatory cells. The …
including hepatocytes, hepatic stellate cells, endothelial cells and inflammatory cells. The …
Acquisition of epithelial plasticity in human chronic liver disease
C Gribben, V Galanakis, A Calderwood, EC Williams… - Nature, 2024 - nature.com
For many adult human organs, tissue regeneration during chronic disease remains a
controversial subject. Regenerative processes are easily observed in animal models, and …
controversial subject. Regenerative processes are easily observed in animal models, and …
[HTML][HTML] Building consensus on definition and nomenclature of hepatic, pancreatic, and biliary organoids
Hepatic, pancreatic, and biliary (HPB) organoids are powerful tools for studying
development, disease, and regeneration. As organoid research expands, the need for clear …
development, disease, and regeneration. As organoid research expands, the need for clear …
Hippo signalling in the liver: role in development, regeneration and disease
The Hippo signalling pathway has emerged as a major player in many aspects of liver
biology, such as development, cell fate determination, homeostatic function and …
biology, such as development, cell fate determination, homeostatic function and …
Spatiotemporal metabolic liver zonation and consequences on pathophysiology
Hepatocytes are the main workers in the hepatic factory, managing metabolism of nutrients
and xenobiotics, production and recycling of proteins, and glucose and lipid homeostasis …
and xenobiotics, production and recycling of proteins, and glucose and lipid homeostasis …
Single-cell technologies in hepatology: new insights into liver biology and disease pathogenesis
Liver disease is a major global health-care problem, affecting an estimated 844 million
people worldwide. Despite this substantial burden, therapeutic options for liver disease …
people worldwide. Despite this substantial burden, therapeutic options for liver disease …
A spatiotemporal atlas of cholestatic injury and repair in mice
Cholestatic liver injuries, characterized by regional damage around the bile ductular region,
lack curative therapies and cause considerable mortality. Here we generated a high …
lack curative therapies and cause considerable mortality. Here we generated a high …