CD47 is an immunoglobulin that is overexpressed on the surface of many types of cancer
cells. CD47 forms a signaling complex with signal-regulatory protein α (SIRPα), enabling the …

CD47, or integrin-associated protein, is a cell surface ligand expressed in low levels by
nearly all cells of the body. It plays an integral role in various immune responses as well as …

Immunotherapy using PD-1 and CTLA4 inhibitors to stimulate T cell immunity has achieved
significant clinical success. However, only a portion of patients benefit from T cell-based …

CD47 is overexpressed in various types of cancers and it can directly bind with SIRPα,
which is mainly located on macrophages. The binding of CD47-SIRPα transmits a “don't eat …

Abstract Cluster of differentiation 47 (CD47) is a transmembrane protein that is ubiquitously
found on the surface of many cells in the body and uniquely overexpressed by both solid …

Background Immunotherapy has emerged as a novel strategy for cancer treatment following
surgery, radiotherapy, and chemotherapy. Immune checkpoint blockade and Chimeric …

As a transmembrane protein, CD47 plays an important role in mediating cell proliferation,
migration, phagocytosis, apoptosis, immune homeostasis, inhibition of NO signal …

Cancer immunotherapy using checkpoint blockade has brought about a paradigm shift in
the treatment of advanced-stage cancers. Unfortunately, not all patients benefit from these …

Cancer is still a major disease that is currently difficult for humans to overcome. When the
expression of the cluster of differentiation 47 (CD47) is upregulated, tumor cells interact with …

ABSTRACT CD47 is known to be involved in phagocyte-mediated tumor clearance;
however, its expression, clinical significance, and regulatory mechanism in hepatocellular …