Metabolites profiling, in-vitro and molecular docking studies of five legume seeds for Alzheimer's disease

RM Ibrahim, PM Abdel-Baki, OG Mohamed… - Scientific Reports, 2024 - nature.com
Even though legumes are valuable medicinal plants with edible seeds that are extensively
consumed worldwide, there is little information available on the metabolic variations …

Essential oils of Plumeria alba L. and Plumeria rubra L. growing in Egypt: GC/MS analysis, molecular dynamics and in-vitro anti-cholinesterase activity

RA El-Shiekh, DE Ali, AA Mandour… - Industrial Crops and …, 2024 - Elsevier
Abstract Aim Essential oils (EOs) from Plumeria species exhibit noteworthy chemical
compositions and diverse biological activities, rendering them valuable constituents for use …

Design and synthesis of new spirooxindole candidates and their selenium nanoparticles as potential dual Topo I/II inhibitors, DNA intercalators, and apoptotic …

S El-Kalyoubi, MM Khalifa, MT Abo-Elfadl… - Journal of Enzyme …, 2023 - Taylor & Francis
A new wave of dual Topo I/II inhibitors was designed and synthesised via the hybridisation
of spirooxindoles and pyrimidines. In situ selenium nanoparticles (SeNPs) for some …

A mechanistic exploration of the metabolome of African mango seeds and its potential to alleviate cognitive impairment induced by high-fat/high-carbohydrate diets …

YR Hassan, RA El-Shiekh, HM El Hefnawy… - Journal of …, 2024 - Elsevier
Abstract Ethnopharmacological relevance Irvingia gabonensis (Aubry-Lecomte ex O'Rorke)
Baill., also known as “African mango” or “bush mango”, belonging to family Irvingiaceae, has …

Community Structure and Diversity of Endophytic Fungi in Cultivated Polygala crotalarioides at Two Different Growth Stages Based on Culture-Independent and …

K Shen, Y **ong, Y Liu, X Fan, R Zhu, Z Hu, C Li… - Journal of Fungi, 2024 - mdpi.com
Polygala crotalarioides, a perennial herbaceous plant found in southwest China, has the
potential to be used in the treatment of Alzheimer's disease. Endophytic fungi that reside …

An Update of Fungal Endophyte Diversity and Strategies for Augmenting Therapeutic Potential of their Potent Metabolites: Recent Advancement

C Prajapati, SN Rai, AK Singh, BA Chopade… - Applied Biochemistry …, 2025 - Springer
Endophytic fungi represent a significant renewable resource for the discovery of
pharmaceutically important compounds, offering substantial potential for new drug …

A comparative analysis of polysaccharides and ethanolic extracts from two Egyptian sweet potato cultivars, Abees and A 195: chemical characterization and …

RM Elgabry, M Hassan, GA Fawzy, KM Meselhy… - Metabolites, 2024 - mdpi.com
Sweet potato (Ipomoea batatas (L.) Lam.) belongs to family Convolvulaceae. The plant is
distributed worldwide and consumed, especially for its edible tubers. Many studies have …

Uncovering the therapeutic potential of green pea waste in breast cancer: a multi-target approach utilizing LC-MS/MS metabolomics, molecular networking, and …

AM Khalil, OM Sabry, HI El-Askary… - … Medicine and Therapies, 2024 - Springer
Background Pisum sativum (PS) is a universal legume plant utilized for both human and
animal consumption, particularly its seeds, known as green peas. The processing of PS in …

Taming food–drug interaction risk: potential inhibitory effects of citrus juices on cytochrome liver enzymes can safeguard the liver from overdose paracetamol-induced …

AS Shalaby, HH Eid, RA El-Shiekh, OG Mohamed… - ACS …, 2023 - ACS Publications
Paracetamol overdose is the leading cause of drug-induced hepatotoxicity worldwide.
Because of N-acetyl cysteine's limited therapeutic efficacy and safety, searching for …

Antioxidant and anticholinesterase properties of Echinometra mathaei and Ophiocoma erinaceus venoms from the Persian Gulf

H Dehghani, M Rashedinia, G Mohebbi… - Frontiers in …, 2024 - frontiersin.org
Introduction: The Persian Gulf is home to a diverse range of marine life, including various
species of fish, crustaceans, mollusks, and echinoderms. This study investigates the …