Organophosphorus compounds and oximes: a critical review
F Worek, H Thiermann, T Wille - Archives of Toxicology, 2020 - Springer
Organophosphorus (OP) pesticides and nerve agents still pose a threat to the population.
Treatment of OP poisoning is an ongoing challenge and burden for medical services …
Treatment of OP poisoning is an ongoing challenge and burden for medical services …
Reactivators of acetylcholinesterase inhibited by organophosphorus nerve agents
G Mercey, T Verdelet, J Renou… - Accounts of chemical …, 2012 - ACS Publications
Since the September 11, 2001, terrorist attacks in the United States, the specter of a
chemical threat against civilian populations has renewed research interest in chemical …
chemical threat against civilian populations has renewed research interest in chemical …
Acetylcholinesterase inhibitors: pharmacology and toxicology
Acetylcholinesterase is involved in the termination of impulse transmission by rapid
hydrolysis of the neurotransmitter acetylcholine in numerous cholinergic pathways in the …
hydrolysis of the neurotransmitter acetylcholine in numerous cholinergic pathways in the …
Metal-involving synthesis and reactions of oximes
DS Bolotin, NA Bokach, MY Demakova… - Chemical …, 2017 - ACS Publications
This review classifies and summarizes the past 10–15 years of advancements in the field of
metal-involving (ie, metal-mediated and metal-catalyzed) reactions of oximes. These …
metal-involving (ie, metal-mediated and metal-catalyzed) reactions of oximes. These …
[HTML][HTML] FDA-approved oximes and their significance in medicinal chemistry
Despite the scientific advancements, organophosphate (OP) poisoning continues to be a
major threat to humans, accounting for nearly one million poisoning cases every year …
major threat to humans, accounting for nearly one million poisoning cases every year …
Catalytic mechanisms for phosphotriesterases
AN Bigley, FM Raushel - Biochimica et Biophysica Acta (BBA)-Proteins and …, 2013 - Elsevier
Phosphotriesters are one class of highly toxic synthetic compounds known as
organophosphates. Wide spread usage of organophosphates as insecticides as well as …
organophosphates. Wide spread usage of organophosphates as insecticides as well as …
Oximes in organophosphate poisoning: 60 years of hope and despair
F Worek, H Thiermann, T Wille - Chemico-biological interactions, 2016 - Elsevier
The high number of annual fatalities following suicidal poisoning by organophosphorus (OP)
pesticides and the recent homicidal use of the chemical warfare nerve agent sarin against …
pesticides and the recent homicidal use of the chemical warfare nerve agent sarin against …
Oximes: Novel therapeutics with anticancer and anti-inflammatory potential
Oximes have been studied for decades because of their significant roles as
acetylcholinesterase reactivators. Over the last twenty years, a large number of oximes have …
acetylcholinesterase reactivators. Over the last twenty years, a large number of oximes have …
The value of novel oximes for treatment of poisoning by organophosphorus compounds
F Worek, H Thiermann - Pharmacology & therapeutics, 2013 - Elsevier
Poisoning by organophosphorus compounds (OP) still is a major therapeutic problem.
Intentional OP pesticide poisoning results in up to 300.000 deaths each year and highly …
Intentional OP pesticide poisoning results in up to 300.000 deaths each year and highly …
A H4SiW12O40-catalyzed three-component tandem reaction for the synthesis of 3, 3-disubstituted isoindolinones
Y Liu, G Zeng, Y Cheng, L Chen, Y Liu, Y Wei… - Chinese Chemical …, 2024 - Elsevier
Abstract AH 4 SiW 12 O 40-catalyzed three-component tandem reaction of 2-acylbenzoic
acids, primary amines and phosphine oxides to form 3, 3-disubstituted isoindolinones was …
acids, primary amines and phosphine oxides to form 3, 3-disubstituted isoindolinones was …