Abstract p21-activated kinases (PAKs) are positioned at the nexus of several oncogenic
signalling pathways. Overexpression or mutational activation of PAK isoforms frequently …

Phosphorylation of proteins is a ubiquitous mechanism of regulating their function,
localization, or activity. Protein kinases, enzymes that use ATP to phosphorylate protein …

Abstract PAKs, p21-activated kinases, play central roles and act as converging junctions for
discrete signals elicited on the cell surface and for a number of intracellular signaling …

Aberrant folding of proteins in the endoplasmic reticulum activates the bifunctional
transmembrane kinase/endoribonuclease Ire1. Ire1 excises an intron from HAC1 messenger …

Protein kinases are pivotal regulators of cell signaling that modulate each other's functions
and activities through site-specific phosphorylation events. These key regulatory …

The p21 activated kinases (Paks) are well known effector proteins for the Rho GTPases
Cdc42 and Rac. The Paks contain 6 members, which fall into 2 families of proteins. The first …

Calcium/calmodulin-dependent kinase II (CaMKII) forms a highly conserved dodecameric
assembly that is sensitive to the frequency of calcium pulse trains. Neither the structure of …

The p21-Activated kinase 1 (PAK1), a member of serine-threonine kinases family, was
initially identified as an interactor of the Rho GTPases RAC1 and CDC42, which affect a …

The p21-activated kinase (PAK) family of serine/threonine kinases is important in
physiological processes including motility, survival, mitosis, transcription and translation …

Summary trans-autophosphorylation is among the most prevalent means of protein kinase
activation, yet its molecular basis is poorly defined. In Toll-like receptor and interleukin-1 …