β‐transducin repeat‐containing protein (β‐TrCP), one of the well‐characterized F‐box
proteins, acts as a substrate receptor and constitutes an active SCFβ‐TrCP E3 ligase with a …

Targeted Protein Degradation (TPD) represented by Proteolysis-Targeting Chimeras
(PROTAC) is the frontier field in the research and development of antitumor therapy, in …

Aberrant WNT signaling drives colorectal cancer (CRC). Here, we identify TIAM1 as a critical
antagonist of CRC progression through inhibiting TAZ and YAP, effectors of WNT signaling …

Epidermal growth factor receptor (EGFR) signaling regulates cell growth and survival, and
its overactivation drives cancer development. One important branch of EGFR signaling is …

Abstract β-TrCP and SKP2 are two well-studied F-box proteins, which often act as
oncogenes. Whether and how they communicate with each other is unknown. Here we …

Summary The small Rho GTPase RAC1 is an essential regulator of cellular signaling that
controls actin rearrangements and cell motility. Here, we identify a novel CUL3 RING …

The dentate gyrus (DG) controls information flow into the hippocampus and is critical for
learning, memory, pattern separation, and spatial coding, while DG dysfunction is …

The E3 ubiquitin ligase HUWE1, deregulated in carcinoma, has been implicated in tumor
formation. Here, we uncover a role for HUWE1 in cell migration and invasion through …

F-box proteins are substrate receptors of the SCF (SKP1-Cullin 1-F-box protein) E3 ubiquitin
ligase that play important roles in a number of physiological processes and activities …

The Tiam family proteins—Tiam1 and Tiam2/STEF—are Rac1-specific Guanine Nucleotide
Exchange Factors (GEFs) with important functions in epithelial, neuronal, immune and other …