Pioneer factors—key regulators of chromatin and gene expression
Pioneer factors are a group of transcription factors with important roles in gene regulation
during development. Their unique ability to bind to compacted chromatin, promoting its …
during development. Their unique ability to bind to compacted chromatin, promoting its …
Epigenetic regulatory layers in the 3D nucleus
Nearly 7 decades have elapsed since Francis Crick introduced the central dogma of
molecular biology, as part of his ideas on protein synthesis, setting the fundamental rules of …
molecular biology, as part of his ideas on protein synthesis, setting the fundamental rules of …
Biophysical forces mediated by respiration maintain lung alveolar epithelial cell fate
Lungs undergo mechanical strain during breathing, but how these biophysical forces affect
cell fate and tissue homeostasis are unclear. We show that biophysical forces through …
cell fate and tissue homeostasis are unclear. We show that biophysical forces through …
Depletion of lamins B1 and B2 promotes chromatin mobility and induces differential gene expression by a mesoscale-motion-dependent mechanism
Background B-type lamins are critical nuclear envelope proteins that interact with the three-
dimensional genomic architecture. However, identifying the direct roles of B-lamins on …
dimensional genomic architecture. However, identifying the direct roles of B-lamins on …
Nucleome programming is required for the foundation of totipotency in mammalian germline development
M Nagano, B Hu, S Yokobayashi, A Yamamura… - The EMBO …, 2022 - embopress.org
Germ cells are unique in engendering totipotency, yet the mechanisms underlying this
capacity remain elusive. Here, we perform comprehensive and in‐depth nucleome analysis …
capacity remain elusive. Here, we perform comprehensive and in‐depth nucleome analysis …
To be or not be (in the LAD): emerging roles of lamin proteins in transcriptional regulation
E Nazer - Biochemical Society Transactions, 2022 - portlandpress.com
Lamins are components of the nuclear lamina, a protein meshwork that underlies the
nuclear membrane. Lamins interact with chromatin in transcriptionally silent regions defined …
nuclear membrane. Lamins interact with chromatin in transcriptionally silent regions defined …
Choreography of lamina‐associated domains: structure meets dynamics
Lamina‐associated domains are large regions of heterochromatin positioned at the nuclear
periphery. These domains have been implicated in gene repression, especially in the …
periphery. These domains have been implicated in gene repression, especially in the …
The secret life of chromatin tethers
The nuclear envelope plays an essential role in organizing the genome inside of the
nucleus. The inner nuclear membrane is coated with a meshwork of filamentous lamin …
nucleus. The inner nuclear membrane is coated with a meshwork of filamentous lamin …
Pioneer factor Pax7 initiates two-step cell-cycle-dependent chromatin opening
A Gouhier, J Dumoulin-Gagnon… - Nature Structural & …, 2024 - nature.com
Pioneer transcription factors direct cell differentiation by deploying new enhancer repertoires
through their unique ability to target and initiate remodelling of closed chromatin. The initial …
through their unique ability to target and initiate remodelling of closed chromatin. The initial …
[HTML][HTML] Enhancers on the edge—How the nuclear envelope controls gene regulatory elements
R Czapiewski, EC Schirmer - Current Opinion in Genetics & Development, 2024 - Elsevier
Highlights●The nuclear envelope (NE) contributes to 3D genome organization regulatory
control.●NE control of their localization affects the function of genes, enhancers, and …
control.●NE control of their localization affects the function of genes, enhancers, and …