Motivation Gaining structural insights into the protein–protein interactome is essential to
understand biological phenomena and extract knowledge for rational drug design or protein …

Abstract Three-dimensional (3D) structures of protein complexes provide fundamental
information to decipher biological processes at the molecular scale. The vast amount of …

Protein homo-oligomerization is a very common phenomenon, and approximately half of
proteins form homo-oligomeric assemblies composed of identical subunits. The vast majority …

Modern structural biology still draws the vast majority of information from crystallography, a
technique where the objects being investigated are embedded in a crystal lattice. Given the …

We present the quality assessment of 5613 models submitted by predictor groups from both
CAPRI and CASP for the total of 15 most tractable targets from the second joint CASP …

The SARS-CoV-2 viral spike protein S receptor-binding domain (S-RBD) binds ACE2 on
host cells to initiate molecular events, resulting in intracellular release of the viral genome …

Ichthyoses are a clinically and genetically heterogeneous group of genodermatoses
associated with abnormal scaling of the skin over the whole body. Mutations in nine genes …

A correct assessment of the quaternary structure of proteins is a fundamental prerequisite to
understanding their function, physico-chemical properties and mode of interaction with other …

Protein structures are key to understanding biomolecular mechanisms and diseases, yet
their interpretation is hampered by limited knowledge of their biologically relevant …

Abstract Structure-based machine learning algorithms have been utilized to predict the
properties of protein-protein interaction (PPI) complexes, such as binding affinity, which is …