Revisiting netrin-1: one who guides (axons)
NP Boyer, SL Gupton - Frontiers in cellular neuroscience, 2018 - frontiersin.org
Proper patterning of the nervous system requires that develo** axons find appropriate
postsynaptic partners; this entails microns to meters of extension through an extracellular …
postsynaptic partners; this entails microns to meters of extension through an extracellular …
Role of Netrin-1 signaling in nerve regeneration
XP Dun, DB Parkinson - International journal of molecular sciences, 2017 - mdpi.com
Netrin-1 was the first axon guidance molecule to be discovered in vertebrates and has a
strong chemotropic function for axonal guidance, cell migration, morphogenesis and …
strong chemotropic function for axonal guidance, cell migration, morphogenesis and …
New insights into the molecular mechanisms of axon guidance receptor regulation and signaling
As the nervous system develops, newly differentiated neurons need to extend their axons
toward their synaptic targets to form functional neural circuits. During this highly dynamic …
toward their synaptic targets to form functional neural circuits. During this highly dynamic …
Structural decoding of the Netrin-1/UNC5 interaction and its therapeutical implications in cancers
Netrin-1 has been shown to be up-regulated in a fraction of human cancers as a mechanism
to allow these tumors to escape the pro-apoptotic activity of some of its main dependence …
to allow these tumors to escape the pro-apoptotic activity of some of its main dependence …
The Netrin-1/DCC guidance system: dopamine pathway maturation and psychiatric disorders emerging in adolescence
Axon guidance molecules direct growing axons toward their targets, assembling the intricate
wiring of the nervous system. One of these molecules, Netrin-1, and its receptor, DCC …
wiring of the nervous system. One of these molecules, Netrin-1, and its receptor, DCC …
Inhibition of tetrameric Patched1 by Sonic Hedgehog through an asymmetric paradigm
Abstract The Hedgehog (Hh) pathway controls embryonic development and postnatal tissue
maintenance and regeneration. Inhibition of Hh receptor Patched (Ptch) by the Hh ligands …
maintenance and regeneration. Inhibition of Hh receptor Patched (Ptch) by the Hh ligands …
Enhanced neuron growth and electrical activity by a supramolecular netrin-1 mimetic nanofiber
Neurotrophic factors are essential not only for guiding the organization of the develo**
nervous system but also for supporting the survival and growth of neurons after traumatic …
nervous system but also for supporting the survival and growth of neurons after traumatic …
The dynamic nature of netrin-1 and the structural basis for glycosaminoglycan fragment-induced filament formation
M Meier, M Gupta, S Akgül, M McDougall… - Nature …, 2023 - nature.com
Netrin-1 is a bifunctional chemotropic guidance cue that plays key roles in diverse cellular
processes including axon pathfinding, cell migration, adhesion, differentiation, and survival …
processes including axon pathfinding, cell migration, adhesion, differentiation, and survival …
Mutations in DCC cause isolated agenesis of the corpus callosum with incomplete penetrance
Brain malformations involving the corpus callosum are common in children with
developmental disabilities. We identified DCC mutations in four families and five sporadic …
developmental disabilities. We identified DCC mutations in four families and five sporadic …
Structural decoding of netrin-4 reveals a regulatory function towards mature basement membranes
Netrins, a family of laminin-related molecules, have been proposed to act as guidance cues
either during nervous system development or the establishment of the vascular system. This …
either during nervous system development or the establishment of the vascular system. This …