Although many biochemical and structural studies have demonstrated that DNA sequences
containing runs of adjacent guanines spontaneously fold into G-quadruplex DNA structures …

In this review, we give an overview of recent literature on the structure and stability of
unimolecular G-rich quadruplex structures that are relevant to drug design and for in vivo …

Four-stranded G-quadruplex nucleic acid structures are of great interest as their high
thermodynamic stability under near-physiological conditions suggests that they could form in …

Abstract G-quadruplex (G4) structural motifs have been linked to transcription 1, 2,
replication 3 and genome instability 4, 5 and are implicated in cancer and other diseases 6 …

Telomeres protect chromosome ends through the interaction of telomeric repeats with
shelterin, a protein complex that represses DNA damage signaling and DNA repair …

Guanine-rich DNA sequences that can adopt non–Watson-Crick structures in vitro are
prevalent in the human genome. Whether such structures normally exist in mammalian cells …

Over the past decade, nucleic acid chemists have seen the spectacular emergence of
molecules designed to interact efficiently and selectively with a peculiar DNA structure …

Telomeres are DNA-protein complexes that cap and protect the ends of linear
chromosomes. In almost all species, telomeric DNA has a G/C strand bias, and the short …

The 3′‐ends of human chromosomal DNA terminate in short single‐stranded guanine‐rich
tandem‐repeat sequences. In cancer cells, these are associated with the telomere …

Nucleic acid sequences containing several short runs of guanine nucleotides can form
complex higher order structures, termed quadruplexes. Their occurrence has been most …