Neurobehavioural comorbidities of epilepsy: towards a network-based precision taxonomy

BP Hermann, AF Struck, RM Busch, A Reyes… - Nature Reviews …, 2021‏ - nature.com
Cognitive and behavioural comorbidities are prevalent in childhood and adult epilepsies
and impose a substantial human and economic burden. Over the past century, the classic …

[HTML][HTML] ABCB1 and ABCG2 regulation at the blood-brain barrier: potential new targets to improve brain drug delivery

JA Schulz, AMS Hartz, B Bauer - Pharmacological Reviews, 2023‏ - Elsevier
The drug efflux transporters ABCB1 and ABCG2 at the blood-brain barrier limit the delivery
of drugs into the brain. Strategies to overcome ABCB1/ABCG2 have been largely …

Behavioral comorbidities of epilepsy and neuroinflammation: Evidence from experimental and clinical studies

EM Suleymanova - Epilepsy & Behavior, 2021‏ - Elsevier
Currently, a significant amount of data is accumulated showing that neuroinflammation is
one of the key processes in the development of brain pathology in trauma …

[HTML][HTML] Epilepsy is more than a simple seizure disorder: causal relationships between epilepsy and its comorbidities

SI Peek, F Twele, S Meller, RMA Packer, HA Volk - The Veterinary Journal, 2024‏ - Elsevier
This review draws connections between the pathogenesis of canine epilepsy and its most
commonly recognised comorbidities: cognitive impairment (CI), attention deficit hyperactivity …

Effectiveness of a self-management program to improve cognition and quality of life in epilepsy: a pragmatic, randomized, multicenter trial

NA Streltzov, SS Schmidt, LM Schommer, W Zhao… - Neurology, 2022‏ - neurology.org
Background and Objectives We conducted a multisite, pragmatic replication trial at 4 New
England epilepsy centers to determine the effectiveness of Home-Based Self-Management …

Characterization of circRNA-associated-ceRNA networks involved in the pathogenesis of postoperative cognitive dysfunction in aging mice

MX Zhang, JR Lin, ST Yang, J Zou, Y Xue… - Frontiers in Aging …, 2022‏ - frontiersin.org
Postoperative cognitive dysfunction (POCD) is a clinical entity associated with declined
cognitive function following surgery. It occurs more frequently in elderly patients. Recent …

Increased cardiovascular risk in epilepsy

ML Gaertner, S Mintzer, CM DeGiorgio - Frontiers in Neurology, 2024‏ - frontiersin.org
Epilepsy is associated with increased mortality. Cardiovascular disease confers a significant
portion of this increased risk. Recently there is increased interest in the burden of …

Stress phenotypes in epilepsy: impact on cognitive functioning and quality of life

J Catalán-Aguilar, E González-Bono… - Frontiers in …, 2023‏ - frontiersin.org
Introduction Drug-resistant epilepsy has been proposed as a chronic stress model. Stress
can be measured in terms of chronicity (epilepsy duration) and intensity (comorbidities), with …

[HTML][HTML] Review of antidepressants in clinic and active ingredients of traditional Chinese medicine targeting 5-HT1A receptors

L Wang, Y Zhang, X Du, T Ding, W Gong… - Biomedicine & …, 2019‏ - Elsevier
Serotonin, which also named as 5-hydroxytryptamine (5-HT), is a neurotransmitter, which
plays significant roles in a wide range of physiological and pathological processes …

Course and prognosis of adult-onset epilepsy in Brazil: A cohort study

ALF Caprara, JP Rissardo, MTB Leite, JOF Silveira… - Epilepsy & Behavior, 2020‏ - Elsevier
Background Most of the epilepsy longitudinal studies have analyzed children. However, in
endemic regions, such as Brazil, neurocysticercosis accounts for many adult-onset epilepsy …