The target of rapamycin (TOR), discovered 30 years ago, is a highly conserved
serine/threonine protein kinase that plays a central role in regulating cell growth and …

The AGC kinase subfamily of protein kinases contains 60 members, including PKA, PKG
and PKC. The family comprises some intensely examined protein kinases (such as Akt, S6K …

The mechanistic target of rapamycin complex 2 (mTORC2) regulates cell survival and
cytoskeletal organization by phosphorylating its AGC kinase substrates; however, little is …

Phosphorylation of proteins is a ubiquitous mechanism of regulating their function,
localization, or activity. Protein kinases, enzymes that use ATP to phosphorylate protein …

The mechanistic target of rapamycin (mTOR) plays a central role in cellular growth and
metabolism. mTOR forms two distinct protein complexes, mTORC1 and mTORC2. Much is …

The complex mTORC2 is accepted to be the kinase that controls the phosphorylation of the
hydrophobic motif, a key regulatory switch for AGC kinases, although whether mTOR directly …

Nestled at the tip of a branch of the kinome, protein kinase C (PKC) family members are
poised to transduce signals emanating from the cell surface. Cell membranes provide the …

Protein kinase C (PKC) is involved in a wide array of cellular processes such as cell
proliferation, differentiation and apoptosis. Phosphorylation of both turn motif (TM) and …

The mammalian target of rapamycin (mTOR) functions within two distinct complexes
(mTORC1 and mTORC2) to control cell growth, proliferation, survival, and metabolism …

The target of rapamycin (TOR), as part of the rapamycin‐sensitive TOR complex 1 (TORC1),
regulates various aspects of protein synthesis. Whether TOR functions in this process as part …