[HTML][HTML] Gut microbiome and health: mechanistic insights
The gut microbiota is now considered as one of the key elements contributing to the
regulation of host health. Virtually all our body sites are colonised by microbes suggesting …
regulation of host health. Virtually all our body sites are colonised by microbes suggesting …
[HTML][HTML] Gut microbiota-derived bile acids in intestinal immunity, inflammation, and tumorigenesis
J Cai, L Sun, FJ Gonzalez - Cell host & microbe, 2022 - cell.com
Inflammatory bowel disease (IBD) and colorectal cancer (CRC) are heterogeneous intestinal
diseases that threaten the health of an increasing number of individuals as their lifestyles …
diseases that threaten the health of an increasing number of individuals as their lifestyles …
SER-109, an Oral Microbiome Therapy for Recurrent Clostridioides difficile Infection
P Feuerstadt, TJ Louie, B Lashner… - … England Journal of …, 2022 - Mass Medical Soc
Background Current therapies for recurrent Clostridioides difficile infection do not address
the disrupted microbiome, which supports C. difficile spore germination into toxin-producing …
the disrupted microbiome, which supports C. difficile spore germination into toxin-producing …
Novel bile acid biosynthetic pathways are enriched in the microbiome of centenarians
Centenarians have a decreased susceptibility to ageing-associated illnesses, chronic
inflammation and infectious diseases 1, 2, 3. Here we show that centenarians have a distinct …
inflammation and infectious diseases 1, 2, 3. Here we show that centenarians have a distinct …
Microbial transformations of human bile acids
Bile acids play key roles in gut metabolism, cell signaling, and microbiome composition.
While the liver is responsible for the production of primary bile acids, microbes in the gut …
While the liver is responsible for the production of primary bile acids, microbes in the gut …
Meta-analysis of fecal metagenomes reveals global microbial signatures that are specific for colorectal cancer
Association studies have linked microbiome alterations with many human diseases.
However, they have not always reported consistent results, thereby necessitating cross …
However, they have not always reported consistent results, thereby necessitating cross …
Bacterial metabolism of bile acids promotes generation of peripheral regulatory T cells
Intestinal health relies on the immunosuppressive activity of CD4+ regulatory T (Treg) cells.
Expression of the transcription factor Foxp3 defines this lineage, and can be induced …
Expression of the transcription factor Foxp3 defines this lineage, and can be induced …
Impact of bacterial metabolites on gut barrier function and host immunity: a focus on bacterial metabolism and its relevance for intestinal inflammation
N Gasaly, P De Vos, MA Hermoso - Frontiers in immunology, 2021 - frontiersin.org
The diverse and dynamic microbial community of the human gastrointestinal tract plays a
vital role in health, with gut microbiota supporting the development and function of the gut …
vital role in health, with gut microbiota supporting the development and function of the gut …
Bile acid metabolism and signaling, the microbiota, and metabolic disease
The diversity, composition, and function of the bacterial community inhabiting the human
gastrointestinal tract contributes to host health through its role in producing energy or …
gastrointestinal tract contributes to host health through its role in producing energy or …
Metformin alters the gut microbiome of individuals with treatment-naive type 2 diabetes, contributing to the therapeutic effects of the drug
H Wu, E Esteve, V Tremaroli, MT Khan, R Caesar… - Nature medicine, 2017 - nature.com
Metformin is widely used in the treatment of type 2 diabetes (T2D), but its mechanism of
action is poorly defined. Recent evidence implicates the gut microbiota as a site of metformin …
action is poorly defined. Recent evidence implicates the gut microbiota as a site of metformin …