The molecular and physical information coded within the extracellular milieu is informing the
development of a new generation of biomaterials for tissue engineering. Several powerful …

Heparan sulfate (HS) polysaccharides are ubiquitous components of the cell surface and
extracellular matrix of all multicellular animals, whereas heparin is present within mast cells …

Abstract I. Introduction 162 II. CHARACTERISTICS OF TANDEM MASS SPECTRA OF
CARBOHYDRATES 163 A. Ionization of Carbohydrates 163 1. Electrospray Ionization (ESI) …

Heparins represent one of the most frequently used pharmacotherapeutics. Discovered
around 1926, routine clinical anticoagulant use of heparin was initiated only after the …

The extracellular environment is largely comprised of complex polysaccharides, which were
historically considered inert materials that hydrated the cells and contributed to the structural …

Extracellular modulation of phenotype is an emerging paradigm in this current postgenomics
age of molecular and cell biology. Glycosaminoglycans (GAGs) are primary components of …

The sulfated polysaccharide heparin has been used as a life-saving anticoagulant in clinics
well before its detailed structure was known. This mini-review is a survey of the evolution in …

Heparin is a highly sulfated, linear polymer that participates in a plethora of biological
processes by interaction with many proteins. The chemical complexity and heterogeneity of …

Heparin and heparan sulfate glycosaminoglycans (HSGAGs) mediate a wide variety of
complex biological processes by specifically binding proteins and modulating their …

Glycosaminoglycans (GAGs), such as heparin or heparan sulfate, are required for the in vivo
function of chemokines. Chemokines play a crucial role in the recruitment of leukocyte …