Triazole demonstrates distinctive physicochemical properties, characterized by weak
basicity, various dipole moments, and significant dual hydrogen bond acceptor and donor …

Molecular hybridization is one of the recent strategies to synthesize a novel hybrid
compound by combining two or more pharmacophoric units. Being a linkage process, it …

In clinical settings, cancer vaccines as monotherapies have displayed limited success
compared to other cancer immunotherapeutic treatments. Nanoscale formulations have the …

Indole derivatives have become an important class of compounds in medicinal chemistry,
recognized for their wide-ranging biological activities and therapeutic potential. This review …

Abstract Six novel ciprofloxacin-1, 2, 3-triazole hybrids (6a-f) were synthesized via click
reaction, by reacting of methyl 1-cyclopropyl-6-fluoro-4-oxo-7-(4-(3-oxobutanoyl) piperazin-1 …

Colorectal (CRC) and gastric cancers (GC) are the most common digestive tract cancers
with a high incidence rate worldwide. The current treatment including surgery …

Colchicine binding site inhibitors (CBSIs) have attracted much attention due to their
antitumor efficacies and the advantages of inhibiting angiogenesis and overcoming …

A new set of 1, 2, 3-triazoles was designed and synthesized to evaluate their potential to
inhibit the growth of cancer cells. Thiazole, thiazolone, and hydrazine as effective fragments …

Dysfunction of the p53 gene and the presence of the MDR1 gene are associated with many
malignant tumors including endometrial cancer and are responsible for cancer therapeutic …

A series of novel thiazole-based chalcones were evaluated for their anticancer activity as
potential tubulin polymerization inhibitors. In vitro anticancer screening for the thiazole …