[HTML][HTML] Stress-induced plasticity and functioning of ventral tegmental dopamine neurons
The ventral tegmental area dopamine (VTA-DA) mesolimbic circuit processes emotional,
motivational, and social reward associations together with their more demanding cognitive …
motivational, and social reward associations together with their more demanding cognitive …
VTA GABA neurons at the interface of stress and reward
C Bouarab, B Thompson, AM Polter - Frontiers in neural circuits, 2019 - frontiersin.org
The ventral tegmental area (VTA) is best known for its robust dopaminergic projections to
forebrain regions and their critical role in regulating reward, motivation, cognition, and …
forebrain regions and their critical role in regulating reward, motivation, cognition, and …
[HTML][HTML] Biphasic activation of WNT signaling facilitates the derivation of midbrain dopamine neurons from hESCs for translational use
Human pluripotent stem cells show considerable promise for applications in regenerative
medicine, including the development of cell replacement paradigms for the treatment of …
medicine, including the development of cell replacement paradigms for the treatment of …
Ca2+ channels couple spiking to mitochondrial metabolism in substantia nigra dopaminergic neurons
How do neurons match generation of adenosine triphosphate by mitochondria to the
bioenergetic demands of regenerative activity? Although the subject of speculation, this …
bioenergetic demands of regenerative activity? Although the subject of speculation, this …
Reward and aversion in a heterogeneous midbrain dopamine system
The ventral tegmental area (VTA) is a heterogeneous brain structure that serves a central
role in motivation and reward processing. Abnormalities in the function of VTA dopamine …
role in motivation and reward processing. Abnormalities in the function of VTA dopamine …
Direct generation of functional dopaminergic neurons from mouse and human fibroblasts
Transplantation of dopaminergic neurons can potentially improve the clinical outcome of
Parkinson's disease, a neurological disorder resulting from degeneration of mesencephalic …
Parkinson's disease, a neurological disorder resulting from degeneration of mesencephalic …
Predictive markers guide differentiation to improve graft outcome in clinical translation of hESC-based therapy for Parkinson's disease
Stem cell treatments for neurodegenerative diseases are expected to reach clinical trials
soon. Most of the approaches currently under development involve transplantation of …
soon. Most of the approaches currently under development involve transplantation of …
Direct conversion of human fibroblasts to dopaminergic neurons
Recent reports demonstrate that somatic mouse cells can be directly converted to other
mature cell types by using combined expression of defined factors. Here we show that the …
mature cell types by using combined expression of defined factors. Here we show that the …
Cortico-basal ganglia reward network: microcircuitry
SR Sesack, AA Grace - Neuropsychopharmacology, 2010 - nature.com
Many of the brain's reward systems converge on the nucleus accumbens, a region richly
innervated by excitatory, inhibitory, and modulatory afferents representing the circuitry …
innervated by excitatory, inhibitory, and modulatory afferents representing the circuitry …
Dopamine, behavior, and addiction
Addictive drugs are habit-forming. Addiction is a learned behavior; repeated exposure to
addictive drugs can stamp in learning. Dopamine-depleted or dopamine-deleted animals …
addictive drugs can stamp in learning. Dopamine-depleted or dopamine-deleted animals …