The importance of fusion protein activity in Ewing sarcoma and the cell intrinsic and extrinsic factors that regulate it: A review
Accumulating evidence shows that despite clonal origins tumors eventually become
complex communities comprised of phenotypically distinct cell subpopulations. This …
complex communities comprised of phenotypically distinct cell subpopulations. This …
Quantitative cell imaging approaches to metastatic state profiling
Genetic heterogeneity of metastatic dissemination has proven challenging to identify
exploitable markers of metastasis; this bottom-up approach has caused a stalemate …
exploitable markers of metastasis; this bottom-up approach has caused a stalemate …
EWS/FLI1 Characterization, Activation, Repression, Target Genes and Therapeutic Opportunities in Ewing Sarcoma
Despite their clonal origins, tumors eventually develop into complex communities made up
of phenotypically different cell subpopulations, according to mounting evidence. Tumor cell …
of phenotypically different cell subpopulations, according to mounting evidence. Tumor cell …
Imaging of cellular dynamics in vitro and in situ: from a whole organism to sub-cellular imaging with self-driving, multi-scale microscopy
Many biological processes span multiple time and length scales, including developmental
processes and cancer metastasis. While light-sheet fluorescence microscopy (LSFM) has …
processes and cancer metastasis. While light-sheet fluorescence microscopy (LSFM) has …
[HTML][HTML] A general algorithm for consensus 3D cell segmentation from 2D segmented stacks
Cell segmentation is the fundamental task. Only by segmenting, can we define the
quantitative spatial unit for collecting measurements to draw biological conclusions. Deep …
quantitative spatial unit for collecting measurements to draw biological conclusions. Deep …
[HTML][HTML] The Vps13-like protein BLTP2 is pro-survival and regulates phosphatidylethanolamine levels in the plasma membrane to maintain its fluidity and function
Lipid transport proteins (LTPs) facilitate nonvesicular lipid exchange between cellular
compartments and have critical roles in lipid homeostasis 1. A new family of bridge-like LTPs …
compartments and have critical roles in lipid homeostasis 1. A new family of bridge-like LTPs …
Cell shape noise strength regulates the rate of shape change during EMT-associated cell spreading
Cellular shape is intimately linked to cell function and state, and transitions between cell
states are tightly coupled to shape changes. Yet, shape has been largely overlooked in state …
states are tightly coupled to shape changes. Yet, shape has been largely overlooked in state …
Caveolin-1 regulates context-dependent signaling and survival in Ewing Sarcoma.
Cellular plasticity is a hallmark function of cancer, but many of the underlying mechanisms
are not well understood. We uncover Caveolin-1, a scaffolding protein that modulates …
are not well understood. We uncover Caveolin-1, a scaffolding protein that modulates …
Form and Fate: The Morphological Landscape of Zebrafish Lateral Line Neuromast Cells
MN Hewitt - 2023 - search.proquest.com
The shape of a cell both influences and is influenced by its fate. However, quantitative
studies of cell shape in living, develo** organisms have been limited in dimension and …
studies of cell shape in living, develo** organisms have been limited in dimension and …