Understanding the immunosuppressive microenvironment of glioma: mechanistic insights and clinical perspectives

H Lin, C Liu, A Hu, D Zhang, H Yang, Y Mao - Journal of hematology & …, 2024 - Springer
Glioblastoma (GBM), the predominant and primary malignant intracranial tumor, poses a
formidable challenge due to its immunosuppressive microenvironment, thereby confounding …

Circadian rhythms, disease and chronotherapy

Y Lee, JM Field, A Sehgal - Journal of biological rhythms, 2021 - journals.sagepub.com
Circadian clocks are biological timing mechanisms that generate 24-h rhythms of physiology
and behavior, exemplified by cycles of sleep/wake, hormone release, and metabolism. The …

Learning from circadian rhythm to transform cancer prevention, prognosis, and survivorship care

X Zhu, G Maier, S Panda - Trends in Cancer, 2024 - cell.com
Circadian timekee** mechanisms and cell cycle regulation share thematic biological
principles in responding to signals, repairing cellular damage, coordinating metabolism, and …

Circadian regulation of cancer cell and tumor microenvironment crosstalk

W Xuan, F Khan, CD James, AB Heimberger… - Trends in Cell …, 2021 - cell.com
Circadian rhythms regulate a remarkable variety of physiologic functions in living organisms.
Circadian disruption is associated with tumorigenesis and tumor progression through effects …

Molecular mechanisms of tumour development in glioblastoma: an emerging role for the circadian clock

N Nelson, A Relógio - NPJ Precision Oncology, 2024 - nature.com
Glioblastoma is one of the most lethal cancers with current therapeutic options lacking major
successes. This underlines the necessity to understand glioblastoma biology on other levels …

Chronotherapy in Glioblastoma: state of the art and future perspectives

M Petković, M Henis, O Heese, A Relógio - EBioMedicine, 2023 - thelancet.com
Circadian rhythms regulate various processes in the human body, including drug
metabolism. Chronotherapy optimizes treatment timing based on the circadian rhythm of the …

Ferroptosis‐Related Gene Signature Promotes Ovarian Cancer by Influencing Immune Infiltration and Invasion

Y You, Q Fan, J Huang, Y Wu, H Lin… - Journal of …, 2021 - Wiley Online Library
Ovarian cancer is a kind of gynecological malignancy with high mortality. Ferroptosis is a
new type of iron‐dependent cell death characterized by the formation of lipid peroxides and …

Characterization of fatty acid metabolism-related genes landscape for predicting prognosis and aiding immunotherapy in glioma patients

F Jiang, F Luo, N Zeng, Y Mao, X Tang… - Frontiers in …, 2022 - frontiersin.org
Glioma is a highly malignant brain tumor with a poor survival rate. The involvement of fatty
acid metabolism in glioma was examined to find viable treatment options. The information …

How does chronobiology contribute to the development of diseases in later life

TA Stowe, CA McClung - Clinical Interventions in Aging, 2023 - Taylor & Francis
An increasingly older population is one of the major social and medical challenges we
currently face. Between 2010 and 2050, it is estimated that the proportion of adults over 65 …

[HTML][HTML] LINC00978 regulates metabolic rewiring to promote the malignancy of glioblastoma through AKR1B1

M Meng, L Yang, H Zhou, Q Cheng, R Peng, Z Wang… - Cancer Letters, 2023 - Elsevier
Glioma is a fatal primary brain tumor. Improved glioma treatment effectiveness depends on a
better understanding of its underlying mechanisms. Glioblastoma (GBM), was classified as …