Studying the Endothelial Glycocalyx in vitro: What Is Missing?

AB Haymet, N Bartnikowski, ES Wood… - Frontiers in …, 2021‏ - frontiersin.org
All human cells are coated by a surface layer of proteoglycans, glycosaminoglycans (GAGs)
and plasma proteins, called the glycocalyx. The glycocalyx transmits shear stress to the …

The use of TKM-100802 and convalescent plasma in 2 patients with Ebola virus disease in the United States

CS Kraft, AL Hewlett, S Koepsell… - Clinical Infectious …, 2015‏ - academic.oup.com
Abstract Background. The current West Africa Ebola virus disease (EVD) outbreak has
resulted in multiple individuals being medically evacuated to other countries for clinical …

Pre-trauma center red blood cell transfusion is associated with improved early outcomes in air medical trauma patients

JB Brown, JL Sperry, A Fombona, TR Billiar… - Journal of the American …, 2015‏ - Elsevier
Background Hemorrhage is the leading cause of survivable death in trauma and
resuscitation strategies including early RBC transfusion have reduced this. Pre-trauma …

Plasma as a resuscitation fluid for volume‐depleted shock: potential benefits and risks

DP van den Brink, DJB Kleinveld, PH Sloos… - …, 2021‏ - pmc.ncbi.nlm.nih.gov
The clinical state of shock constitutes a relative or absolute deficiency of circulating volume
for adequate oxygen delivery to meet the metabolic demands. 1 Although shock states differ …

Effect of transfusion of fresh frozen plasma on parameters of endothelial condition and inflammatory status in non-bleeding critically ill patients: a prospective substudy …

M Straat, MCA Müller, JCM Meijers, MS Arbous… - Critical care, 2015‏ - Springer
Introduction Much controversy exists on the effect of a fresh frozen plasma (FFP) transfusion
on systemic inflammation and endothelial damage. Adverse effects of FFP have been well …

Pretrauma center red blood cell transfusion is associated with reduced mortality and coagulopathy in severely injured patients with blunt trauma

JB Brown, MJ Cohen, JP Minei, RV Maier… - Annals of …, 2015‏ - journals.lww.com
Objective: To evaluate the association of pretrauma center (PTC) red blood cell (RBC)
transfusion with outcomes in severely injured patients. Background: Hemorrhage remains a …

Plasma cytokines and markers of endothelial activation increase after packed red blood cell transfusion in the preterm infant

AK Keir, AJ McPhee, CC Andersen, MJ Stark - Pediatric research, 2013‏ - nature.com
Background: Transfusion of packed red blood cells (PRBCs) saves lives in the neonatal
critical care setting and is one of the most common interventions in the preterm infant. The …

Shorter times to packed red blood cell transfusion are associated with decreased risk of death in traumatically injured patients

EK Powell, WR Hinckley, A Gottula… - Journal of Trauma …, 2016‏ - journals.lww.com
BACKGROUND Hemorrhage is a leading cause of death in traumatically injured patients.
Currently, the importance of earlier administration of packed red blood cells (pRBC) to …

Association between perioperative blood transfusion and early postoperative cognitive dysfunction in aged patients following total hip replacement surgery

SH Zhu, MH Ji, DP Gao, WY Li… - Upsala journal of medical …, 2014‏ - Taylor & Francis
Introduction. Accumulating evidence suggests that enhanced inflammatory responses
contribute to the pathogenesis of postoperative cognitive dysfunction (POCD). Blood …

Cardiopulmonary bypass during cardiac surgery modulates systemic inflammation by affecting different steps of the leukocyte recruitment cascade

J Rossaint, C Berger, H Van Aken, HH Scheld… - 2012‏ - journals.plos.org
Background It is known that the use of a cardiopulmonary bypass (CPB) during cardiac
surgery leads to leukocyte activation and may, among other causes, induce organ …