Blood-brain barrier dysfunction and recovery after ischemic stroke
X Jiang, AV Andjelkovic, L Zhu, T Yang… - Progress in …, 2018 - Elsevier
The blood-brain barrier (BBB) plays a vital role in regulating the trafficking of fluid, solutes
and cells at the blood-brain interface and maintaining the homeostatic microenvironment of …
and cells at the blood-brain interface and maintaining the homeostatic microenvironment of …
Astrocyte activation in neurovascular damage and repair following ischaemic stroke
A Patabendige, A Singh, S Jenkins, J Sen… - International journal of …, 2021 - mdpi.com
Transient or permanent loss of tissue perfusion due to ischaemic stroke can lead to damage
to the neurovasculature, and disrupt brain homeostasis, causing long-term motor and …
to the neurovasculature, and disrupt brain homeostasis, causing long-term motor and …
Therapeutic potential of vasopressin in the treatment of neurological disorders
S Mishra, J Grewal, P Wal, GU Bhivshet, AK Tripathi… - Peptides, 2024 - Elsevier
Vasopressin (VP) is a nonapeptide made of nine amino acids synthesized by the
hypothalamus and released by the pituitary gland. VP acts as a neurohormone …
hypothalamus and released by the pituitary gland. VP acts as a neurohormone …
The vascular basement membrane in the healthy and pathological brain
MS Thomsen, LJ Routhe… - Journal of Cerebral Blood …, 2017 - journals.sagepub.com
The vascular basement membrane contributes to the integrity of the blood-brain barrier
(BBB), which is formed by brain capillary endothelial cells (BCECs). The BCECs receive …
(BBB), which is formed by brain capillary endothelial cells (BCECs). The BCECs receive …
Molecular pathophysiology of cerebral edema
JA Stokum, V Gerzanich… - Journal of Cerebral Blood …, 2016 - journals.sagepub.com
Advancements in molecular biology have led to a greater understanding of the individual
proteins responsible for generating cerebral edema. In large part, the study of cerebral …
proteins responsible for generating cerebral edema. In large part, the study of cerebral …
Astrocytes, therapeutic targets for neuroprotection and neurorestoration in ischemic stroke
Astrocytes are the most abundant cell type within the central nervous system. They play
essential roles in maintaining normal brain function, as they are a critical structural and …
essential roles in maintaining normal brain function, as they are a critical structural and …
Implications of MMP9 for blood brain barrier disruption and hemorrhagic transformation following ischemic stroke
Numerous studies have documented increases in matrix metalloproteinases (MMPs),
specifically MMP-9 levels following stroke, with such perturbations associated with …
specifically MMP-9 levels following stroke, with such perturbations associated with …
Neurovascular Unit: A critical role in ischemic stroke
L Wang, X **ong, L Zhang… - CNS Neuroscience & …, 2021 - Wiley Online Library
Ischemic stroke (IS), a common cerebrovascular disease, results from a sudden blockage of
a blood vessel in the brain, thereby restricting blood supply to the area in question, and …
a blood vessel in the brain, thereby restricting blood supply to the area in question, and …
Transmembrane proteins of the tight junctions at the blood–brain barrier: structural and functional aspects
RF Haseloff, S Dithmer, L Winkler, H Wolburg… - Seminars in cell & …, 2015 - Elsevier
The blood–brain barrier (BBB) is formed by microvascular endothelial cells sealed by
tetraspanning tight junction (TJ) proteins, such as claudins and TAMPs (TJ-associated …
tetraspanning tight junction (TJ) proteins, such as claudins and TAMPs (TJ-associated …
Matrix metalloproteinases and blood-brain barrier disruption in acute ischemic stroke
SE Lakhan, A Kirchgessner, D Tepper… - Frontiers in …, 2013 - frontiersin.org
Ischemic stroke continues to be one of the most challenging diseases in translational
neurology. Tissue plasminogen activator (tPA) remains the only approved treatment for …
neurology. Tissue plasminogen activator (tPA) remains the only approved treatment for …