Intestinal in vitro and ex vivo Models to Study Host-Microbiome Interactions and Acute Stressors

SC Pearce, HG Coia, JP Karl… - Frontiers in …, 2018 - frontiersin.org
The gut microbiome is extremely important for maintaining homeostasis with host intestinal
epithelial, neuronal, and immune cells and this host-microbe interaction is critical during …

The porcine innate immune system: an update

KH Mair, C Sedlak, T Käser, A Pasternak… - Developmental & …, 2014 - Elsevier
Over the last few years, we have seen an increasing interest and demand for pigs in
biomedical research. Domestic pigs (Sus scrofa domesticus) are closely related to humans …

Rotavirus interactions with host intestinal epithelial cells

JO Amimo, SA Raev, J Chepngeno… - Frontiers in …, 2021 - frontiersin.org
Rotavirus (RV) is the foremost enteric pathogen associated with severe diarrheal illness in
young children (< 5years) and animals worldwide. RV primarily infects mature enterocytes in …

[HTML][HTML] Human-derived probiotic Lactobacillus reuteri strains differentially reduce intestinal inflammation

Y Liu, NY Fatheree, N Mangalat… - American Journal of …, 2010 - journals.physiology.org
Lactobacillus reuteri (L. reuteri) is a probiotic that inhibits the severity of enteric infections
and modulates the immune system. Human-derived L. reuteri strains DSM17938, ATCC …

Type III interferon restriction by porcine epidemic diarrhea virus and the role of viral protein nsp1 in IRF1 signaling

Q Zhang, H Ke, A Blikslager, T Fujita, D Yoo - Journal of virology, 2018 - journals.asm.org
Type III interferons (IFNs) play a vital role in maintaining the antiviral state of the mucosal
epithelial surface in the gut, and in turn, enteric viruses may have evolved to evade the type …

Porcine IPEC-J2 intestinal epithelial cells in microbiological investigations

AJ Brosnahan, DR Brown - Veterinary microbiology, 2012 - Elsevier
IPEC-J2 cells are porcine intestinal columnar epithelial cells that were isolated from
neonatal piglet mid-jejunum. This cell line forms polarized monolayers with high …

Individual and combined cytotoxic effects of Fusarium toxins (deoxynivalenol, nivalenol, zearalenone and fumonisins B1) on swine jejunal epithelial cells

LYM Wan, PC Turner, H El-Nezami - Food and Chemical Toxicology, 2013 - Elsevier
Fusarium mycotoxins occur worldwide in foods such as cereals and animal forages, leading
to acute and chronic exposures in human and animals. Intestinal epithelial cells (IECs) are …

Polyphenols from brown seaweeds as a potential antimicrobial agent in animal feeds

L Ford, AC Stratakos, K Theodoridou, JTA Dick… - Acs Omega, 2020 - ACS Publications
Seaweeds offer a natural source of antimicrobials that may help curb antibiotic resistance in
livestock. The antibacterial activity of phlorotannin extracts isolated from two brown …

Protective effects of Lactobacillus plantarum on epithelial barrier disruption caused by enterotoxigenic Escherichia coli in intestinal porcine epithelial cells

Y Wu, C Zhu, Z Chen, Z Chen, W Zhang, X Ma… - Veterinary immunology …, 2016 - Elsevier
Tight junctions (TJs) play an important role in maintaining the mucosal barrier function and
gastrointestinal health of animals. Lactobacillus plantarum (L. plantarum) was reported to …

Short-chain fatty acid butyrate, a breast milk metabolite, enhances immature intestinal barrier function genes in response to inflammation in vitro and in vivo

Y Gao, B Davis, W Zhu, N Zheng… - American Journal of …, 2021 - journals.physiology.org
Infants born under 1,500 g have an increased incidence of necrotizing enterocolitis in the
ileum and the colon, which is a life-threatening intestinal necrosis. This is in part due to …