[HTML][HTML] NADPH oxidases (NOX): an overview from discovery, molecular mechanisms to physiology and pathology

A Vermot, I Petit-Härtlein, SME Smith, F Fieschi - Antioxidants, 2021 - mdpi.com
The reactive oxygen species (ROS)-producing enzyme NADPH oxidase (NOX) was first
identified in the membrane of phagocytic cells. For many years, its only known role was in …

Signal pathways of melanoma and targeted therapy

W Guo, H Wang, C Li - Signal transduction and targeted therapy, 2021 - nature.com
Melanoma is the most lethal skin cancer that originates from the malignant transformation of
melanocytes. Although melanoma has long been regarded as a cancerous malignancy with …

Oxidative stress in cancer cell metabolism

S Arfin, NK Jha, SK Jha, KK Kesari, J Ruokolainen… - Antioxidants, 2021 - mdpi.com
Reactive oxygen species (ROS) are important in regulating normal cellular processes
whereas deregulated ROS leads to the development of a diseased state in humans …

The multifaceted role of reactive oxygen species in tumorigenesis

A Kirtonia, G Sethi, M Garg - Cellular and Molecular Life Sciences, 2020 - Springer
Redox homeostasis is an essential requirement of the biological systems for performing
various normal cellular functions including cellular growth, differentiation, senescence …

[HTML][HTML] Role of reactive oxygen species in cancer progression: molecular mechanisms and recent advancements

V Aggarwal, HS Tuli, A Varol, F Thakral, MB Yerer… - Biomolecules, 2019 - mdpi.com
Reactive oxygen species (ROS) play a pivotal role in biological processes and continuous
ROS production in normal cells is controlled by the appropriate regulation between the silver …

Induction of metastasis, cancer stem cell phenotype, and oncogenic metabolism in cancer cells by ionizing radiation

SY Lee, EK Jeong, MK Ju, HM Jeon, MY Kim, CH Kim… - Molecular cancer, 2017 - Springer
Radiation therapy is one of the major tools of cancer treatment, and is widely used for a
variety of malignant tumours. Radiotherapy causes DNA damage directly by ionization or …

Oxidative stress and cancer: an overview

V Sosa, T Moliné, R Somoza, R Paciucci… - Ageing research …, 2013 - Elsevier
Reactive species, which mainly include reactive oxygen species (ROS), are products
generated as a consequence of metabolic reactions in the mitochondria of eukaryotic cells …

[HTML][HTML] Macrophage Akt1 kinase-mediated mitophagy modulates apoptosis resistance and pulmonary fibrosis

JL Larson-Casey, JS Deshane, AJ Ryan… - Immunity, 2016 - cell.com
Idiopathic pulmonary fibrosis (IPF) is a devastating lung disorder with increasing incidence.
Mitochondrial oxidative stress in alveolar macrophages is directly linked to pulmonary …

[HTML][HTML] The double-edged sword of oxidative stress in skin damage and melanoma: From physiopathology to therapeutical approaches

M Emanuelli, D Sartini, E Molinelli, R Campagna… - Antioxidants, 2022 - mdpi.com
The skin is constantly exposed to exogenous and endogenous sources of reactive oxygen
species (ROS). An adequate balance between ROS levels and antioxidant defenses is …

Reactive oxygen species in cancer

GY Liou, P Storz - Free radical research, 2010 - Taylor & Francis
Elevated rates of reactive oxygen species (ROS) have been detected in almost all cancers,
where they promote many aspects of tumour development and progression. However …