The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase receptor that is
frequently expressed in epithelial tumors. The EGFR was the first receptor to be proposed as …

Proper patterning of the nervous system requires that develo** axons find appropriate
postsynaptic partners; this entails microns to meters of extension through an extracellular …

We have developed a potent, histone deacetylase 8 (HDAC8)-specific inhibitor PCI-34051
with> 200-fold selectivity over the other HDAC isoforms. PCI-34051 induces caspase …

The contribution of adipose-derived FGF21 to energy homeostasis is unclear. Here we show
that browning of inguinal white adipose tissue (iWAT) by β-adrenergic agonists requires …

Current research on inositols mainly focuses on myo-inositol (Ins) derivatives in eukaryotic
cells, and in particular on the many roles of Ins phospholipids and polyphosphorylated Ins …

The genus Trichoderma contains fungi with high relevance for humans, with applications in
enzyme production for plant cell wall degradation and use in biocontrol. Here, we provide a …

Cell signaling plays a critical role in neurodevelopment, regulating cellular behavior and
fate. While multimodal single-cell sequencing technologies are rapidly advancing, scalable …

Excessive bone resorption plays a central role on the development of bone erosive
diseases, including osteoporosis, rheumatoid arthritis, and periodontitis. Osteoclasts, bone …

Despite numerous therapies, cancer remains one of the leading causes of death worldwide
due to the lack of markers for early detection and response to treatment in many patients …

Leptin can exert its potent appetite-suppressing effects via activation of hypothalamic
proopiomelanocortin (POMC) neurons. It depolarizes POMC neurons via activation of a yet …