Pioneer factors are transcription factors with the unique ability to initiate opening of closed
chromatin. The stability of cell identity relies on robust mechanisms that maintain the …

Epigenetic research has accelerated rapidly in the twenty-first century, generating justified
excitement and hope, but also a degree of hype. Here we review how the field has evolved …

Pioneer factors are a subclass of transcription factors that can bind and initiate opening of
silent chromatin regions. Pioneer factors subsequently regulate lineage-specific genes and …

For cells to initiate and sustain a differentiated state, it is necessary that a 'memory'of this
state is transmitted through mitosis to the daughter cells,–. Mammalian switch/sucrose non …

Pioneer transcription factors have the unique and important role of unmasking chromatin
domains during development to allow the implementation of new cellular programs …

Although the genome is generally thought to be transcriptionally silent during mitosis,
technical limitations have prevented sensitive map** of transcription during mitosis and …

A strong connection exists between the cell cycle and mechanisms required for executing
cell fate decisions in a wide-range of developmental contexts. Terminal differentiation is …

Despite the fact that the cell cycle is a fundamental process of life, a detailed quantitative
understanding of gene regulation dynamics throughout the cell cycle is far from complete …

During self-renewal, cell-type-defining features are drastically perturbed in mitosis and must
be faithfully reestablished upon G1 entry, a process that remains largely elusive. Here, we …

Mitotic bookmarking transcription factors (TFs) are thought to mediate rapid and accurate
reactivation after mitotic gene silencing. However, the loss of individual bookmarking TFs …