Abstract Molecular Lego: Polyketides represent a highly diverse group of natural products
with structurally intriguing carbon skeletons (see picture) which are assembled from simple …

Fungi have proved to be a rich and important source of a huge number of secondary
metabolites with a large variety of chemical structures and diverse biological activities …

Decarboxylation strategy has been emerging as a powerful tool for the synthesis of fluorine-
containing organic compounds that play important roles in various fields such as …

The macrocyclic core of the antibiotic erythromycin, 6-deoxyerythronolide B (6dEB), is a
complex natural product synthesized by the soil bacterium Saccharopolyspora erythraea …

Type II polyketide synthases: gaining a deeper insight into enzymatic teamwork Page 1
REVIEW www.rsc.org/npr | Natural Product Reports Type II polyketide synthases: gaining a …

Polyketides, the ubiquitous products of secondary metabolism in microorganisms, are made
by a process resembling fatty acid biosynthesis that allows the suppression of reduction or …

Plants, marine organisms, and microorganisms have evolved complex chemical defense
and signaling systems that are designed to protect them from predators and provide other …

Over the last eight years or so, genetic techniques have spearheaded significant advances
in our understanding of the structure and mechanisms of polyketide synthases (PKSs). Much …

Polyketides represent an important class of biologically active and structurally diverse
compounds in nature. They are synthesized from acyl‐coenzyme A substrates by polyketide …

The structures of complex polyketide natural products, such as erythromycin, are
programmed by multifunctional polyketide synthases (PKSs) that contain modular …