Background Non-alcoholic fatty liver disease, or as recently proposed 'metabolic-associated
fatty liver disease'(MAFLD), is characterized by pathological accumulation of triglycerides …

Highlights•Traditional calorie restriction robustly improves markers of aging in
humans.•Novel dietary strategies may be substitutes for calorie restriction.•Intermittent …

High protein intake is common in western societies and is often promoted as part of a
healthy lifestyle; however, amino-acid-mediated mammalian target of rapamycin (mTOR) …

Dietary protein restriction is increasingly recognized as a unique approach to improve
metabolic health, and there is increasing interest in the mechanisms underlying this …

Reduced protein intake, through dilution with carbohydrate, extends lifespan and improves
mid-life metabolic health in animal models. However, with transition to industrialised food …

Dietary protein dilution (DPD) promotes metabolic-remodelling and-health but the precise
nutritional components driving this response remain elusive. Here, by mimicking amino acid …

Plant-based dietary patterns are associated with improved cardiometabolic health, but
causal dietary components are unclear. Protein has been proposed to play a role, but the …

The prevalence of obesity is a worldwide phenomenon in all age groups and is associated
with aging-related diseases such as type 2 diabetes, as well metabolic and cardiovascular …

The liver is a major metabolic organ that regulates the whole-body metabolic homeostasis
and controls hepatocyte proliferation and growth. The ATF/CREB family of transcription …

While proteins have been widely used to encapsulate, protect, and regulate the release of
bioactive food compounds, little is known about the influence of co‐consumed proteins on …