One leading hypothesis suggests that memories are stored in ensembles of neurons (or
'engram cells') and that successful recall involves reactivation of these ensembles. A logical …

Major depressive disorder (MDD) will affect one out of every five people in their lifetime and
is the leading cause of disability worldwide. Nevertheless, mechanisms associated with the …

Autism spectrum disorder (ASD) is a set of neurodevelopmental disorders with a high
prevalence and impact on society. ASDs are characterized by deficits in both social behavior …

For more than 20 years, we have known that Ca2+/calmodulin-dependent protein kinase
(CaMKII) activation is both necessary and sufficient for the induction of long-term …

Rho‐associated kinase (Rho‐kinase/ROCK/ROK) is an effector of the small GTPase Rho
and belongs to the AGC family of kinases. Rho‐kinase has pleiotropic functions including …

Schizophrenia is a neurodevelopmental disorder whose clinical features include
impairments in perception, cognition and motivation. These impairments reflect alterations in …

▪ Abstract Neurotrophins regulate development, maintenance, and function of vertebrate
nervous systems. Neurotrophins activate two different classes of receptors, the Trk family of …

Neurodegenerative disorders like Parkinson's disease, Alzheimer's disease, or amyotrophic
lateral sclerosis are affecting a rapidly increasing population worldwide. While common …

Much evidence indicates that, after learning, memories are created by alterations in
glutamate-dependent excitatory synaptic transmission. These modifications are then actively …

The assembly of functional neural circuits requires the combined action of progressive and
regressive events. Regressive events encompass a variety of inhibitory developmental …