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Thrombolysis for acute ischaemic stroke: current status and future perspectives
Alteplase is currently the only approved thrombolytic agent for treatment of acute ischaemic
stroke, but interest is burgeoning in the development of new thrombolytic agents for systemic …
stroke, but interest is burgeoning in the development of new thrombolytic agents for systemic …
Thrombectomy alone versus intravenous alteplase plus thrombectomy in patients with stroke: an open-label, blinded-outcome, randomised non-inferiority trial
Background Whether thrombectomy alone is equally as effective as intravenous alteplase
plus thrombectomy remains controversial. We aimed to determine whether thrombectomy …
plus thrombectomy remains controversial. We aimed to determine whether thrombectomy …
Value of intravenous thrombolysis in endovascular treatment for large-vessel anterior circulation stroke: individual participant data meta-analysis of six randomised …
CB Majoie, F Cavalcante, J Gralla, P Yang… - The lancet, 2023 - thelancet.com
Background Intravenous thrombolysis is recommended before endovascular treatment, but
its value has been questioned in patients who are admitted directly to centres capable of …
its value has been questioned in patients who are admitted directly to centres capable of …
Tenecteplase versus alteplase for acute ischemic stroke: a systematic review and meta-analysis of randomized and non-randomized studies
Objective Alteplase is the current standard of care for acute ischemic stroke. Tenecteplase is
a newer fibrinolytic agent with preferable administration and lower costs; however, its …
a newer fibrinolytic agent with preferable administration and lower costs; however, its …
Time to treatment with intravenous thrombolysis before thrombectomy and functional outcomes in acute ischemic stroke: a meta-analysis
J Kaesmacher, F Cavalcante, M Kappelhof… - Jama, 2024 - jamanetwork.com
Importance The benefit of intravenous thrombolysis (IVT) for acute ischemic stroke declines
with longer time from symptom onset, but it is not known whether a similar time dependency …
with longer time from symptom onset, but it is not known whether a similar time dependency …
Safety and efficacy of tenecteplase in patients with wake-up stroke assessed by non-contrast CT (TWIST): a multicentre, open-label, randomised controlled trial
MB Roaldsen, A Eltoft, T Wilsgaard… - The Lancet …, 2023 - thelancet.com
Background Current evidence supports the use of intravenous thrombolysis with alteplase in
patients with wake-up stroke selected with MRI or perfusion imaging and is recommended in …
patients with wake-up stroke selected with MRI or perfusion imaging and is recommended in …
Assessment of thrombectomy versus combined thrombolysis and thrombectomy in patients with acute ischemic stroke and medium vessel occlusion
Background The combination of intravenous thrombolysis (IVT) with mechanical
thrombectomy (MT) may have clinical benefits for patients with medium vessel occlusion …
thrombectomy (MT) may have clinical benefits for patients with medium vessel occlusion …
Shorter door-to-needle times are associated with better outcomes after intravenous thrombolytic therapy and endovascular thrombectomy for acute ischemic stroke
Background: Existing data and clinical trials could not determine whether faster intravenous
thrombolytic therapy (IVT) translates into better long-term functional outcomes after acute …
thrombolytic therapy (IVT) translates into better long-term functional outcomes after acute …
Advances in mechanical thrombectomy for acute ischaemic stroke
O Raha, C Hall, A Malik, L D'Anna, K Lobotesis… - BMJ …, 2023 - pmc.ncbi.nlm.nih.gov
Mechanical thrombectomy is a ground breaking treatment for acute ischaemic stroke caused
by occlusion of a large vessel. Its efficacy over intravenous thrombolysis has been proven in …
by occlusion of a large vessel. Its efficacy over intravenous thrombolysis has been proven in …
Endovascular thrombectomy for anterior circulation large vessel occlusion stroke: an evolution of trials
N Starikova, S Räty, D Strbian, DPO Kaiser… - Seminars in …, 2023 - thieme-connect.com
The last decade's progress in demonstrating the clinical benefit of endovascular
thrombectomy (EVT) in patients with large vessel occlusion stroke has transformed the …
thrombectomy (EVT) in patients with large vessel occlusion stroke has transformed the …