Migraine is a common and disabling primary headache disorder with a significant
socioeconomic burden. The management of migraine is multifaceted and is generally …

Objective To provide evidence‐based treatment recommendations for adults with acute
migraine who require treatment with injectable medication in an emergency department …

Background: Migraine is one of the most frequent disabling neurological conditions with a
major impact on the patients' quality of life. Objectives: To give evidence‐based or expert …

Currently, migraine is treated mainly by targeting calcitonin gene-related peptides, although
the efficacy of this method is limited and new treatment strategies are desired …

The first edition of the Italian diagnostic and therapeutic guidelines for primary headaches in
adults was published in J Headache Pain 2 (Suppl. 1): 105–190 (2001). Ten years later, the …

Background There is a considerable amount of practice variation in managing migraines in
emergency settings, and evidence-based therapies are often not used first line. Methods A …

Cortical spreading depolarization (CSD) induces pro-inflammatory gene expression in brain
tissue. However, previous studies assessing the relationship between CSD and …

Objective: To determine dosing and side effects of dihydroergotamine as they affect
outcomes in primary headache disorders. Methods: We audited our use of …

Objective.—The final section of this 3‐part review analyzes published reports involving the
acute treatment of migraine with opioids, non‐steroidal anti‐inflammatory drugs (NSAIDs) …

Objective: We compared the efficacy of IV valproate with metoclopramide and with ketorolac
in patients presenting to an emergency department (ED) with acute migraine. Methods: This …