Activated B cells participate in either extrafollicular (EF) or germinal center (GC) responses.
Canonical responses are composed of a short wave of plasmablasts (PBs) arising from EF …

The tumor necrosis factor (TNF) and TNF receptor (TNFR) superfamilies (TNFSF/TNFRSF)
include 19 ligands and 29 receptors that play important roles in the modulation of cellular …

Many common variants have been associated with hematological traits, but identification of
causal genes and pathways has proven challenging. We performed a genome-wide …

Secretory IgA (SIgA) is the dominant antibody class in mucosal secretions. The majority of
plasma cells producing IgA are located within mucosal membranes lining the intestines …

The BAFF-receptor (BAFFR) is encoded by the TNFRSF13C gene and is one of the main pro-
survival receptors in B cells. Its function is impressively documented in humans by a …

The International Collaboration in Asthma, Allergy and Immunology initiated an international
coalition among the American Academy of Allergy, Asthma & Immunology; the European …

The abundance of innate and adaptive immune cells that reside together with trillions of
beneficial commensal microorganisms in the mammalian gastrointestinal tract requires …

We performed a genome-wide association study (GWAS) of IgA nephropathy (IgAN), the
most common form of glomerulonephritis, with discovery and follow-up in 20,612 individuals …

B cells develop from hematopoietic precursor cells in an ordered maturation and selection
process. Extensive studies with many different mouse mutants provided fundamental …

Non-infectious complications in common variable immunodeficiency (CVID) have emerged
as a major clinical challenge. Detailed clinical spectrum, organ-specific pathologies and …