Neutrophil phenotypes and functions in cancer: A consensus statement

DF Quail, B Amulic, M Aziz, BJ Barnes… - Journal of Experimental …, 2022 - rupress.org
Neutrophils are the first responders to infection and inflammation and are thus a critical
component of innate immune defense. Understanding the behavior of neutrophils as they …

Obesity, inflammation, and immune system in osteoarthritis

U Nedunchezhiyan, I Varughese, ARJ Sun… - Frontiers in …, 2022 - frontiersin.org
Obesity remains the most important risk factor for the incidence and progression of
osteoarthritis (OA). The leading cause of OA was believed to be overloading the joints due to …

Combating osteoporosis and obesity with exercise: leveraging cell mechanosensitivity

GM Pagnotti, M Styner, G Uzer, VS Patel… - Nature Reviews …, 2019 - nature.com
Osteoporosis, a condition of skeletal decline that undermines quality of life, is treated with
pharmacological interventions that are associated with poor adherence and adverse effects …

Neutrophils actively contribute to obesity-associated inflammation and pathological complications

E Uribe-Querol, C Rosales - Cells, 2022 - mdpi.com
Obesity is characterized by an increase in body weight associated with an exaggerated
enlargement of the adipose tissue. Obesity has serious negative effects because it is …

The complex immunological and inflammatory network of adipose tissue in obesity

V Apostolopoulos, MPJ De Courten… - Molecular nutrition & …, 2016 - Wiley Online Library
A number of approaches have been utilized in the prevention, management, and treatment
of obesity, including, surgery, medication, diet, exercise, and overall lifestyle changes …

Mechanisms contributing to adverse outcomes of COVID-19 in obesity

M Sudhakar, SB Winfred, G Meiyazhagan… - Molecular and cellular …, 2022 - Springer
A growing amount of epidemiological data from multiple countries indicate an increased
prevalence of obesity, more importantly central obesity, among hospitalized subjects with …

IL-1 family cytokine pathways underlying NAFLD: towards new treatment strategies

AM Mirea, CJ Tack, T Chavakis, LAB Joosten… - Trends in molecular …, 2018 - cell.com
Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide.
Pathways responsible for the activation of IL-1 family cytokines are key in the development …

An update on immune dysregulation in obesity‐related insulin resistance

G Daryabor, D Kabelitz… - Scandinavian journal of …, 2019 - Wiley Online Library
Obesity is associated with chronic low‐grade inflammation of the adipose tissue (AT) that
might develop into systemic inflammation, insulin resistance (IR) and an increased risk of …

Macrophages, chronic inflammation, and insulin resistance

H Li, Y Meng, S He, X Tan, Y Zhang, X Zhang, L Wang… - Cells, 2022 - mdpi.com
The prevalence of obesity has reached alarming levels, which is considered a major risk
factor for several metabolic diseases, including type 2 diabetes (T2D), non-alcoholic fatty …

Neutrophils in host defense, healing, and hypersensitivity: Dynamic cells within a dynamic host

M Siwicki, P Kubes - Journal of Allergy and Clinical Immunology, 2023 - Elsevier
Neutrophils are cells of the innate immune system that are extremely abundant in vivo and
respond quickly to infection, injury, and inflammation. Their constant circulation throughout …