A time to fast

A Di Francesco, C Di Germanio, M Bernier, R De Cabo - Science, 2018 - science.org
Nutrient composition and caloric intake have traditionally been used to devise optimized
diets for various phases of life. Adjustment of meal size and frequency have emerged as …

Flip** the metabolic switch: understanding and applying the health benefits of fasting

SD Anton, K Moehl, WT Donahoo, K Marosi, SA Lee… - …, 2018 - Wiley Online Library
Objective Intermittent fasting (IF) is a term used to describe a variety of eating patterns in
which no or few calories are consumed for time periods that can range from 12 hours to …

Gut microbiota mediates intermittent-fasting alleviation of diabetes-induced cognitive impairment

Z Liu, X Dai, H Zhang, R Shi, Y Hui, X **… - Nature …, 2020 - nature.com
Cognitive decline is one of the complications of type 2 diabetes (T2D). Intermittent fasting
(IF) is a promising dietary intervention for alleviating T2D symptoms, but its protective effect …

Intermittent and periodic fasting, longevity and disease

VD Longo, M Di Tano, MP Mattson, N Guidi - Nature aging, 2021 - nature.com
Intermittent and periodic fasting (IF and PF, respectively) are emerging as safe strategies to
affect longevity and healthspan by acting on cellular aging and disease risk factors, while …

[HTML][HTML] Mitochondrial (dys) function and insulin resistance: from pathophysiological molecular mechanisms to the impact of diet

D Sergi, N Naumovski, LK Heilbronn… - Frontiers in …, 2019 - frontiersin.org
Mitochondrial dysfunction has been implicated in the pathogenesis of insulin resistance, the
hallmark of type 2 diabetes mellitus (T2DM). However, the cause-effect relationship remains …

Fasting, circadian rhythms, and time-restricted feeding in healthy lifespan

VD Longo, S Panda - Cell metabolism, 2016 - cell.com
Most animals alternate periods of feeding with periods of fasting often coinciding with sleep.
Upon> 24 hr of fasting, humans, rodents, and other mammals enter alternative metabolic …

[HTML][HTML] Fasting: molecular mechanisms and clinical applications

VD Longo, MP Mattson - Cell metabolism, 2014 - cell.com
Fasting has been practiced for millennia, but, only recently, studies have shed light on its
role in adaptive cellular responses that reduce oxidative damage and inflammation, optimize …

Ecotoxicity of phenol and cresols to aquatic organisms: A review

W Duan, F Meng, H Cui, Y Lin, G Wang, J Wu - … and environmental safety, 2018 - Elsevier
With the development of industrial production and continuous demand for chemicals, a large
volume of wastewater containing phenols was discharged into the aquatic environment …

The hormesis principle of neuroplasticity and neuroprotection

MP Mattson, RK Leak - Cell Metabolism, 2024 - cell.com
Animals live in habitats fraught with a range of environmental challenges to their bodies and
brains. Accordingly, cells and organ systems have evolved stress-responsive signaling …

Intermittent fasting enhances long-term memory consolidation, adult hippocampal neurogenesis, and expression of longevity gene Klotho

GP Dias, T Murphy, D Stangl, S Ahmet, B Morisse… - Molecular …, 2021 - nature.com
Daily calorie restriction (CR) and intermittent fasting (IF) enhance longevity and cognition but
the effects and mechanisms that differentiate these two paradigms are unknown. We …