Glial cell-derived neurotrophic factor (GDNF), and the neurotrophin nerve growth factor
(NGF) and brain-derived neurotrophic factor (BDNF) are important for the survival …

The extracellular signal-regulated kinase (ERK) pathway is a member of the mitogen-
activated protein kinase (MAPK) superfamily, which is an important, highly conserved family …

It has been well documented that neurotrophins, including brain-derived neurotrophic factor
(BDNF), are severely affected in Alzheimer's disease (AD), but their administration faces a …

Huntington's disease (HD) is caused by an expansion of the polyglutamine tract at the N
terminus of huntingtin. This mutation reduces levels of BDNF in the striatum, likely by …

Huntington's disease (HD) is a fatal degenerative autosomal dominant neuropsychiatric
disease that causes neuronal death and is characterized by progressive striatal and then …

Brain-derived neurotrophic factor (BDNF) has been found to play roles in many types of
plasticity including drug addiction. Here, we focus on rodent studies over the past two …

This review will provide an overview of the non-drug based approaches that have been
demonstrated to enhance cognitive function of the compromised brain, primarily focussed on …

Loss of neurotrophic support in the striatum caused by reduced brain-derived neurotrophic
factor (BDNF) levels plays a critical role in Huntington's disease (HD) pathogenesis. BDNF …

Huntington's disease (HD) is a hereditary neurodegenerative disorder characterized by
motor and cognitive impairments, involving striatum, cortex and hippocampus. Synaptic and …

Impaired hippocampal synaptic plasticity contributes to cognitive impairment in Huntington's
disease (HD). However, the molecular basis of such synaptic plasticity defects is not fully …