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Scientific rationale for develo** potent RBD-based vaccines targeting COVID-19
H Kleanthous, JM Silverman, KW Makar, IK Yoon… - npj Vaccines, 2021 - nature.com
Vaccination of the global population against COVID-19 is a great scientific, logistical, and
moral challenge. Despite the rapid development and authorization of several full-length …
moral challenge. Despite the rapid development and authorization of several full-length …
Whole inactivated virus and protein-based COVID-19 vaccines
The rapid development and deployment of mRNA and adenovirus-vectored vaccines
against coronavirus disease 2019 (COVID-19) continue to astound the global scientific …
against coronavirus disease 2019 (COVID-19) continue to astound the global scientific …
An aluminum hydroxide: CpG adjuvant enhances protection elicited by a SARS-CoV-2 receptor binding domain vaccine in aged mice
Global deployment of vaccines that can provide protection across several age groups is still
urgently needed to end the COVID-19 pandemic, especially in low-and middle-income …
urgently needed to end the COVID-19 pandemic, especially in low-and middle-income …
Synthetic biology-inspired cell engineering in diagnosis, treatment and drug development
N Zhao, Y Song, X ** synthetic biology (SB) has provided many genetic tools to reprogram
and engineer cells for improved performance, novel functions, and diverse applications …
and engineer cells for improved performance, novel functions, and diverse applications …
[HTML][HTML] Evaluation of safety and immunogenicity of receptor-binding domain-based COVID-19 vaccine (Corbevax) to select the optimum formulation in open-label …
S Thuluva, V Paradkar, SR Gunneri, V Yerroju… - …, 2022 - thelancet.com
Background We assessed the efficacy of a receptor-binding domain (RBD)-based protein
subunit COVID-19 vaccine. Methods A randomised Phase-1/2 trial followed by a Phase-2 …
subunit COVID-19 vaccine. Methods A randomised Phase-1/2 trial followed by a Phase-2 …
A yeast-expressed RBD-based SARS-CoV-2 vaccine formulated with 3M-052-alum adjuvant promotes protective efficacy in non-human primates
Ongoing severe acute respiratory syndrome coronavirus–2 (SARS-CoV-2) vaccine
development is focused on identifying stable, cost-effective, and accessible candidates for …
development is focused on identifying stable, cost-effective, and accessible candidates for …
SARS‑CoV-2 RBD219-N1C1: A yeast-expressed SARS-CoV-2 recombinant receptor-binding domain candidate vaccine stimulates virus neutralizing antibodies and T …
There is an urgent need for an accessible and low-cost COVID-19 vaccine suitable for low-
and middle-income countries. Here, we report on the development of a SARS-CoV-2 …
and middle-income countries. Here, we report on the development of a SARS-CoV-2 …
SARS-CoV-2 RBD trimer protein adjuvanted with Alum-3M-052 protects from SARS-CoV-2 infection and immune pathology in the lung
There is a great need for the development of vaccines that induce potent and long-lasting
protective immunity against SARS-CoV-2. Multimeric display of the antigen combined with …
protective immunity against SARS-CoV-2. Multimeric display of the antigen combined with …
[HTML][HTML] An engineered SARS-CoV-2 receptor-binding domain produced in Pichia pastoris as a candidate vaccine antigen
M Limonta-Fernández, G Chinea-Santiago… - New …, 2022 - Elsevier
Develo** affordable and easily manufactured SARS-CoV-2 vaccines will be essential to
achieve worldwide vaccine coverage and long-term control of the COVID-19 pandemic …
achieve worldwide vaccine coverage and long-term control of the COVID-19 pandemic …
From concept to delivery: a yeast-expressed recombinant protein-based COVID-19 vaccine technology suitable for global access
Introduction The development of a yeast-expressed recombinant protein-based vaccine
technology co-developed with LMIC vaccine producers and suitable as a COVID-19 vaccine …
technology co-developed with LMIC vaccine producers and suitable as a COVID-19 vaccine …