Scientific rationale for develo** potent RBD-based vaccines targeting COVID-19

H Kleanthous, JM Silverman, KW Makar, IK Yoon… - npj Vaccines, 2021 - nature.com
Vaccination of the global population against COVID-19 is a great scientific, logistical, and
moral challenge. Despite the rapid development and authorization of several full-length …

Whole inactivated virus and protein-based COVID-19 vaccines

PJ Hotez, ME Bottazzi - Annual Review of Medicine, 2022 - annualreviews.org
The rapid development and deployment of mRNA and adenovirus-vectored vaccines
against coronavirus disease 2019 (COVID-19) continue to astound the global scientific …

An aluminum hydroxide: CpG adjuvant enhances protection elicited by a SARS-CoV-2 receptor binding domain vaccine in aged mice

E Nanishi, F Borriello, TR O'Meara… - Science translational …, 2021 - science.org
Global deployment of vaccines that can provide protection across several age groups is still
urgently needed to end the COVID-19 pandemic, especially in low-and middle-income …

Synthetic biology-inspired cell engineering in diagnosis, treatment and drug development

N Zhao, Y Song, X ** synthetic biology (SB) has provided many genetic tools to reprogram
and engineer cells for improved performance, novel functions, and diverse applications …

[HTML][HTML] Evaluation of safety and immunogenicity of receptor-binding domain-based COVID-19 vaccine (Corbevax) to select the optimum formulation in open-label …

S Thuluva, V Paradkar, SR Gunneri, V Yerroju… - …, 2022 - thelancet.com
Background We assessed the efficacy of a receptor-binding domain (RBD)-based protein
subunit COVID-19 vaccine. Methods A randomised Phase-1/2 trial followed by a Phase-2 …

A yeast-expressed RBD-based SARS-CoV-2 vaccine formulated with 3M-052-alum adjuvant promotes protective efficacy in non-human primates

M Pino, T Abid, S Pereira Ribeiro, VV Edara… - Science …, 2021 - science.org
Ongoing severe acute respiratory syndrome coronavirus–2 (SARS-CoV-2) vaccine
development is focused on identifying stable, cost-effective, and accessible candidates for …

SARS‑CoV-2 RBD219-N1C1: A yeast-expressed SARS-CoV-2 recombinant receptor-binding domain candidate vaccine stimulates virus neutralizing antibodies and T …

J Pollet, WH Chen, L Versteeg, B Keegan… - Human vaccines & …, 2021 - Taylor & Francis
There is an urgent need for an accessible and low-cost COVID-19 vaccine suitable for low-
and middle-income countries. Here, we report on the development of a SARS-CoV-2 …

SARS-CoV-2 RBD trimer protein adjuvanted with Alum-3M-052 protects from SARS-CoV-2 infection and immune pathology in the lung

NK Routhu, N Cheedarla, VS Bollimpelli… - Nature …, 2021 - nature.com
There is a great need for the development of vaccines that induce potent and long-lasting
protective immunity against SARS-CoV-2. Multimeric display of the antigen combined with …

[HTML][HTML] An engineered SARS-CoV-2 receptor-binding domain produced in Pichia pastoris as a candidate vaccine antigen

M Limonta-Fernández, G Chinea-Santiago… - New …, 2022 - Elsevier
Develo** affordable and easily manufactured SARS-CoV-2 vaccines will be essential to
achieve worldwide vaccine coverage and long-term control of the COVID-19 pandemic …

From concept to delivery: a yeast-expressed recombinant protein-based COVID-19 vaccine technology suitable for global access

PJ Hotez, R Adhikari, WH Chen, YL Chen… - Expert Review of …, 2023 - Taylor & Francis
Introduction The development of a yeast-expressed recombinant protein-based vaccine
technology co-developed with LMIC vaccine producers and suitable as a COVID-19 vaccine …