Oligomers which form during amyloid fibril assembly are considered to be key contributors
towards amyloid disease. However, understanding how such intermediates form, their …

In biology, it can be argued that if the genome contains the script for a cell's life cycle, then
the proteome constitutes an ensemble cast of actors that brings these instructions to life …

Ligand binding affinity calculations based on molecular dynamics (MD) simulations and non-
physical (alchemical) thermodynamic cycles have shown great promise for structure-based …

Solid-state NMR spectroscopy (ssNMR) with magic-angle spinning (MAS) enables the
investigation of biological systems within their native context, such as lipid membranes, viral …

Cardiac involvement has a profound effect on the prognosis of patients with systemic
amyloidosis. Therapeutic methods for suppressing the production of causative proteins have …

α-, β-, and γ-Synuclein are intrinsically disordered proteins implicated in physiological
processes in the nervous system of vertebrates. α-synuclein (αSyn) is the amyloidogenic …

Amyloid transthyretin (ATTR) amyloidosis is characterized by the abnormal accumulation of
ATTR fibrils in multiple organs. However, the structure of ATTR fibrils from the eye is poorly …

Hereditary amyloidogenic transthyretin (ATTRv) amyloidosis is a rare autosomal dominantly
inherited disorder caused by mutations in the transthyretin (TTR) gene. The pathogenetic …

Long-chain unsaturated and polyunsaturated fatty acids (LCUFAs and LCPUFAs,
respectively) are the essential components of phospholipids and sphingolipids, major …

The progressive accumulation of transthyretin (TTR), a small protein that transports
thyroxine, in various organs and tissues is observed upon transthyretin amyloidosis, a …