Recent applications of 1, 3-thiazole core structure in the identification of new lead compounds and drug discovery
Thiazole is one of the most important scaffolds in heterocyclic chemistry and drug design
and discovery. It is widely found in diverse pharmacologically active substances and in …
and discovery. It is widely found in diverse pharmacologically active substances and in …
Recent developments of 2-aminothiazoles in medicinal chemistry
Abstract The 2-aminothiazole (2-AT) core is an active pharmacophore and used in medicinal
chemistry and drug discovery research. A number of drugs with 2-AT core are in the market …
chemistry and drug discovery research. A number of drugs with 2-AT core are in the market …
Development of novel indolin-2-one derivative incorporating thiazole moiety as DHFR and quorum sensing inhibitors: Synthesis, antimicrobial, and antibiofilm …
Nowadays, it's imperative to develop novel antimicrobial agents active against both drug-
sensitive and drug-resistant bacterial infections with favorable profiles as high efficacy, low …
sensitive and drug-resistant bacterial infections with favorable profiles as high efficacy, low …
Recent developments in azole compounds as antibacterial and antifungal agents
XM Peng, GX Cai, CH Zhou - Current Topics in Medicinal …, 2013 - ingentaconnect.com
Azole compounds are an important class of nitrogen heterocycles with electron-rich
property. This special structure endows azole-based derivatives easily bind with the …
property. This special structure endows azole-based derivatives easily bind with the …
Synthesis, crystal structure, Hirshfeld surface investigation and comparative DFT studies of ethyl 2-[2-(2-nitrobenzylidene) hydrazinyl] thiazole-4-carboxylate
Abstract The ethyl 2-[2-(2-nitrobenzylidene) hydrazinyl] thiazole-4-carboxylate (1), a thiazole
ester, was synthesized by refluxing 1-(2-nitrobenzylidene) thiosemicarbazide and ethyl …
ester, was synthesized by refluxing 1-(2-nitrobenzylidene) thiosemicarbazide and ethyl …
Synthesis, antibacterial and antioxidant activities of Thiazole-based Schiff base derivatives: a combined experimental and computational study
Abstract Background Thiazole-based Schiff base compounds display significant
pharmacological potential with an ability to modulate the activity of many enzymes involved …
pharmacological potential with an ability to modulate the activity of many enzymes involved …
Synthesis, Structural Characterization, Cytotoxicity, and Protein/DNA Binding Properties of Pyridoxylidene-Aminoguanidine-Metal (Fe, Co, Zn, Cu) Complexes
Pyridoxylidene-aminoguanidine (PLAG) and its transition metal complexes are biologically
active compounds with interesting properties. In this contribution, three new metal-PLAG …
active compounds with interesting properties. In this contribution, three new metal-PLAG …
A retrospect on antimicrobial potential of thiazole scaffold
Due to its appreciable diversity in biological actions, thiazole and its substituted
components, a significant class of heterocyclic compounds has developed as an influential …
components, a significant class of heterocyclic compounds has developed as an influential …
Pyrazolopyrimidines as anticancer agents: A review on structural and target-based approaches
Pyrazolopyrimidine scaffold is one of the privileged heterocycles in drug discovery. This
scaffold produced numerous biological activities in which anticancer is important one …
scaffold produced numerous biological activities in which anticancer is important one …
Synthesis and biological evaluation of coumarin appended thiazole hybrid heterocycles: Antibacterial and antifungal study
In the present investigation, a series of 3-(1-(2-(thiazol-2-yl) hydrazineylidene) ethyl)-2H-
chromen-2-one derivatives are synthesized in good to excellent yield using PEG-400 as a …
chromen-2-one derivatives are synthesized in good to excellent yield using PEG-400 as a …