The protective blood–brain barrier has a major role in ensuring normal brain function by
severely limiting and tightly controlling the ingress of substances into the brain from the …

The CNS critically relies on the formation and proper function of its vasculature during
development, adult homeostasis and disease. Angiogenesis—the formation of new blood …

Tumor microenvironments are the result of cellular alterations in cancer that support
unrestricted growth and proliferation and result in further modifications in cell behavior …

Simple Summary This paper summarizes the crosstalk between tumor/non-tumor cells and
other elements of the glioblastoma (GB) microenvironment. In tumor pathology, glial cells …

Glioblastoma, a subset of aggressive brain tumors, deploy several means to increase blood
vessel supply dedicated to the tumor mass. This includes typical program borrowed from …

Simple Summary Glioblastoma (GBM) is the most common form of primary malignant brain
tumor with a devastatingly poor prognosis. Tumor heterogeneity (cellular, molecular and …

Simple Summary Glioblastoma stem-like cells (GSCs) drive the progression and therapeutic
resistance of glioblastoma. GSC plasticity allows them to adapt to different …

Aims Anti-angiotherapy (Bevacizumab) is currently regarded as a promising option for
glioma patients who are resistant to temozolomide (TMZ) treatment. But ongoing clinical …

Glioblastoma and other brain or CNS malignancies (like neuroblastoma and
medulloblastoma) are difficult to treat and are characterized by excessive vascularization …

The concepts of hematopoiesis and the generation of blood and immune cells from
hematopoietic stem cells are some steady concepts in the field of hematology. However, the …