COVID-19 currently represents one of the major health challenges worldwide. Albeit its
infectious character, with onset affectation mainly at the respiratory track, it is clear that the …

Genome-scale metabolic models (GEMs) have found numerous applications in different
domains, ranging from biotechnology to systems medicine. Herein, we overview the most …

Plasma of COVID-19 patients contains a strong metabolomic/lipoproteomic signature,
revealed by the NMR analysis of a cohort of> 500 patients sampled during various waves of …

Coronavirus disease 2019 (COVID-19) is triggered by the SARS-CoV-2, which is able to
infect and cause dysfunction not only in lungs, but also in multiple organs, including central …

In this paper, a fuzzy hierarchical optimization framework is proposed for identifying potential
antiviral targets for treating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …

Concerns about the SARS-CoV-2 outbreak (COVID-19) continue to persist even years later,
with the emergence of new variants and the risk of disease severity. Common clinical …

Identifying specific diagnostic and prognostic biological markers of COVID-19 can improve
disease surveillance and therapeutic opportunities. Mass spectrometry combined with …

We investigated the effects of obesity on metabolic, inflammatory, and oxidative stress
parameters in the adipose tissue of patients with fatal COVID‐19. Postmortem biopsies of …

The acylcarnitines comprise a wide range of acyl groups linked via an ester bond to the
hydroxyl group of L-carnitine. Mass spectrometry methods are capable of measuring the …

Computational systems biology plays a key role in the discovery of suitable antiviral targets.
We designed a cell‐specific, constraint‐based modeling technique for severe acute …