Neutrophils are formidable defenders. Their vast numbers, constant production, high
cytotoxicity and capacity to produce extracellular traps, underlie their ability to efficiently …

Leukocyte migration is a fundamental component of innate and adaptive immune responses
as it governs the recruitment and localization of these motile cells, which is crucial for …

The circadian clock has sway on a myriad of physiological targets, among which the immune
and inflammatory systems are particularly prominent. In this review, we discuss how …

Enterotoxigenic Escherichia coli (ETEC) are a major cause of diarrheal illness in humans
and animals, induced by enterotoxins produced by these pathogens. Despite the crucial role …

CXCL12 and its receptor CXCR4 emerge as critical regulators within the intricate network of
processes ensuring skin homeostasis. In this review, we discuss their spatial distribution and …

Neutrophils need to migrate through tight tissue spaces to eliminate pathogens, but their
movement is often hindered by their large and stiff nuclei. Neutrophil migration is impaired in …

Chemokines are mainly studied for their local function in the control of leukocyte
extravasation in homeostatic and inflammatory conditions. However, they have additional …

Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer, and the infiltration
of leukemic cells is critical for disease progression and relapse. Nuclear deformability plays …

Cells navigating in complex 3D microenvironments frequently encounter narrow spaces that
physically challenge migration. While in vitro studies identified nuclear stiffness as a key rate …

Epigenetic alterations are hallmarks of cancer, with histone modifiers playing critical roles in
gene transcription, DNA homeostasis, and other nuclear functions. Lysine-specific …