Genetically encoded small molecules (secondary metabolites) play eminent roles in
ecological interactions, as pathogenicity factors and as drug leads. Yet, these chemical …

It is almost a century since nisin was discovered in fermented milk cultures, coincidentally in
the same year that penicillin was first described. Over the last 100 years this small, highly …

Natural Products (NP) are essential for the discovery of novel drugs and products for
numerous biotechnological applications. The NP discovery process is expensive and time …

Bacteria provide a rich source of natural products with potential therapeutic applications,
such as novel antibiotic classes or anticancer drugs. Bioactivity-guided screening of …

Human-associated bacteria secrete modified peptides to control host physiology and
remodel the microbiota species composition. Here we scanned 2,229 Human Microbiome …

Covering: 2016 to 2021 With genetic information available for hundreds of thousands of
organisms in publicly accessible databases, scientists have an unprecedented opportunity …

Lasso peptides are a large and sequence-diverse class of ribosomally synthesized and post-
translationally modified peptide (RiPP) natural products characterized by their slip knot-like …

Natural products remain a critical source of medicines and drug leads. One of the most
rapidly growing superclasses of natural products is RiPPs: ribosomally synthesized and …

Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a growing
class of natural products that benefited from genome sequencing technology in the past two …

The total synthesis and structural elucidation of the antimicrobial sactipeptide enteropeptin A
is reported. Enteropeptin A contains a thioaminoketal group with an unassigned …