Triggering receptor expressed on myeloid cells 2 (TREM2) is a single-pass transmembrane
immune receptor that is mainly expressed on microglia in the brain and macrophages in the …

Obesity is a chronic and progressive process affecting whole-body energy balance and is
associated with comorbidity development. In addition to increased fat mass, obesity induces …

Obesity-induced chronic liver inflammation is a hallmark of nonalcoholic steatohepatitis
(NASH)—an aggressive form of nonalcoholic fatty liver disease. However, it remains unclear …

Adipose tissue macrophage (ATM) has been appreciated for its critical contribution to
obesity-associated metabolic diseases in recent years. Here, we discuss the regulation of …

A chronic low-grade inflammation within adipose tissue (AT) seems to be the link between
obesity and some of its associated diseases. One hallmark of this AT inflammation is the …

Abstract Background Adipose tissue macrophages (ATMs) are a well characterized
regulator of adipose tissue inflammatory tone. Previously defined by the M1 vs M2 …

Macrophages are professional phagocytes, indispensable for maintenance of tissue
homeostasis and integrity. Depending on their resident tissue, macrophages are exposed to …

In obesity, sustained adipose tissue (AT) inflammation constitutes a cellular memory that
limits the effectiveness of weight loss interventions. Yet, the impact of fasting regimens on …

Macrophages are key multi-talented cells of the innate immune system and are equipped
with receptors involved in damage and pathogen recognition with connected immune …

Identifying molecular circuits that control adipose tissue macrophage (ATM) function is
necessary to understand how ATMs contribute to tissue homeostasis and obesity-induced …