Combating antimicrobial resistance via single-cell diagnostic technologies powered by droplet microfluidics
Conspectus Antimicrobial resistance is a global threat that if left unchecked could lead to 10
million annual mortalities by 2050. One factor contributing to the rise of multi-drug-resistant …
million annual mortalities by 2050. One factor contributing to the rise of multi-drug-resistant …
[HTML][HTML] Advances in Host Depletion and Pathogen Enrichment Methods for Rapid Sequencing–Based Diagnosis of Bloodstream Infection
Bloodstream infection is a major cause of morbidity and death worldwide. Timely and
appropriate treatment can reduce mortality among critically ill patients. Current diagnostic …
appropriate treatment can reduce mortality among critically ill patients. Current diagnostic …
A Cascaded Droplet Microfluidic Platform Enables High‐Throughput Single Cell Antibiotic Susceptibility Testing at Scale
The global threat of antibiotic resistance underscores critical but unmet needs for rapid
antibiotic susceptibility testing (AST) technologies. To this end, droplet microfluidic‐based …
antibiotic susceptibility testing (AST) technologies. To this end, droplet microfluidic‐based …
Direct single-cell antimicrobial susceptibility testing of Escherichia coli in urine using a ready-to-use 3D microwell array chip
Empirical antibiotic therapies are prescribed for treating uncomplicated urinary tract
infections (UTIs) due to the long turnaround time of conventional antimicrobial susceptibility …
infections (UTIs) due to the long turnaround time of conventional antimicrobial susceptibility …
Label-free 1D microfluidic dipstick counting of microbial colonies and bacteriophage plaques
Counting viable bacterial cells and functional bacteriophage is fundamental to microbiology
underpinning research, surveillance, biopharmaceuticals and diagnostics. Colony forming …
underpinning research, surveillance, biopharmaceuticals and diagnostics. Colony forming …
Vancomycin-conjugated polydopamine-coated magnetic nanoparticles for molecular diagnostics of Gram-positive bacteria in whole blood
Background Sepsis is caused mainly by infection in the blood with a broad range of bacterial
species. It can be diagnosed by molecular diagnostics once compounds in the blood that …
species. It can be diagnosed by molecular diagnostics once compounds in the blood that …
Moving microcapillary antibiotic susceptibility testing (mcAST) towards the clinic: unravelling kinetics of detection of uropathogenic E. coli, mass-manufacturing and …
SH Needs, J Pivetal, J Hayward, SP Kidd… - Sensors & …, 2023 - pubs.rsc.org
Innovation in infection based point-of-care (PoC) diagnostics is vital to avoid unnecessary
use of antibiotics and the development of antimicrobial resistance. Several groups including …
use of antibiotics and the development of antimicrobial resistance. Several groups including …
[HTML][HTML] Combining deep learning and droplet microfluidics for rapid and label-free antimicrobial susceptibility testing of colistin
J Riti, G Sutra, T Naas, H Volland, S Simon… - Biosensors and …, 2024 - Elsevier
Efficient tools for rapid antibiotic susceptibility testing (AST) are crucial for appropriate use of
antibiotics, especially colistin, which is now often considered a last resort therapy with …
antibiotics, especially colistin, which is now often considered a last resort therapy with …
Miniaturised broth microdilution for simplified antibiotic susceptibility testing of Gram negative clinical isolates using microcapillary devices
Antibiotic resistance is a major global challenge. Although microfluidic antibiotic
susceptibility tests (AST) offer great potential for rapid and portable testing to inform correct …
susceptibility tests (AST) offer great potential for rapid and portable testing to inform correct …
Quantitative assessment of automated purification and concentration of E. coli bacteria
NSF Guzmán, MW Badawy, MA Stockslager, ML Farrell… - SLAS technology, 2023 - Elsevier
Automated methods for rapidly purifying and concentrating bacteria from environmental
interferents are needed in next-generation applications for anything from water purification …
interferents are needed in next-generation applications for anything from water purification …