[HTML][HTML] The nicotinamide/streptozotocin rodent model of type 2 diabetes: renal pathophysiology and redox imbalance features

LJ Yan - Biomolecules, 2022‏ - mdpi.com
Diabetic nephropathy (DN) is a common complication of diabetes mellitus. While there has
been a great advance in our understanding of the pathogenesis of DN, no effective …

Regulation of carbohydrate metabolism by nitric oxide and hydrogen sulfide: Implications in diabetes

S Gheibi, AP Samsonov, S Gheibi, AB Vazquez… - Biochemical …, 2020‏ - Elsevier
Nitric oxide (NO) and hydrogen sulfide (H 2 S) are two gasotransmitters that are produced in
the human body and have a key role in many of the physiological activities of the various …

Insulin secretion: The nitric oxide controversy

S Gheibi, A Ghasemi - EXCLI journal, 2020‏ - pmc.ncbi.nlm.nih.gov
Nitric oxide (NO) is a gas that serves as a ubiquitous signaling molecule participating in
physiological activities of various organ systems. Nitric oxide is produced in the endocrine …

Interaction among hydrogen sulfide and other gasotransmitters in mammalian physiology and pathophysiology

YQ Huang, HF **, H Zhang, CS Tang… - Advances in Hydrogen …, 2021‏ - Springer
Abstract Hydrogen sulfide (H 2 S), nitric oxide (NO), carbon monoxide (CO), and sulfur
dioxide (SO 2) were previously considered as toxic gases, but now they are found to be …

Lost-in-translation of metabolic effects of inorganic nitrate in type 2 diabetes: is ascorbic acid the answer?

Z Bahadoran, P Mirmiran, K Kashfi… - International Journal of …, 2021‏ - mdpi.com
Beneficial metabolic effects of inorganic nitrate (NO3−) and nitrite (NO2−) in type 2 diabetes
mellitus (T2DM) have been documented in animal experiments; however, this is not the case …

Anti‐obesity effects of Beta vulgaris and Eruca sativa‐based extracts

M Markou, A Katsouda, V Papaioannou… - Phytotherapy …, 2024‏ - Wiley Online Library
Obesity is a major source of morbidity worldwide with more than 2 billion adults being
overweight or obese. The incidence of obesity has tripled in the last 50 years, leading to an …

Effect of inorganic nitrate on metabolic parameters in patients with type 2 diabetes: A 24-week randomized double-blind placebo-controlled clinical trial

Z Bahadoran, R Norouzirad, P Mirmiran, Z Gaeini… - Nitric Oxide, 2021‏ - Elsevier
Aim In this randomized placebo-controlled clinical trial, effect of oral inorganic nitrate (NO
3−) on metabolic parameters was assessed in patients with type 2 diabetes mellitus (T2DM) …

Hydrogen sulfide potentiates the protective effects of nitrite against myocardial ischemia-reperfusion injury in type 2 diabetic rats

S Jeddi, S Gheibi, H Afzali, M Carlström, K Kashfi… - Nitric Oxide, 2022‏ - Elsevier
Decreased heart levels of nitric oxide (NO) and hydrogen sulfide (H 2 S) in type 2 diabetes
(T2D) are associated with a higher risk of mortality following ischemia-reperfusion (IR) injury …

Long-term co-administration of sodium nitrite and sodium hydrosulfide inhibits hepatic gluconeogenesis in male type 2 diabetic rats: Role of PI3K-Akt-eNOS pathway

S Jeddi, S Gheibi, M Carlström, K Kashfi, A Ghasemi - Life Sciences, 2021‏ - Elsevier
Objective A deficiency in hydrogen sulfide (H 2 S) and nitric oxide (NO) contributes to the
development of type 2 diabetes (T2D). An inhibitory effect on liver gluconeogenesis has …

Long-term nitrate administration increases expression of browning genes in epididymal adipose tissue of male type 2 diabetic rats

S Jeddi, N Yousefzadeh, H Afzali, A Ghasemi - Gene, 2021‏ - Elsevier
Expression of browning genes are lower in both humans and animals with type 2 diabetes
(T2D). This study aims at determining effects of long-term nitrate administration on protein …