Lipid-based drug delivery systems, or lipidic carriers, are being extensively employed to
enhance the bioavailability of poorly-soluble drugs. They have the ability to incorporate both …

Over the past decade, we have seen rapid advances in applying nanotechnology in
biomedical areas including bioimaging, biodetection, and drug delivery. As an emerging …

Hydrogels are high-water content materials prepared from cross-linked polymers that are
able to provide sustained, local delivery of a variety of therapeutic agents. Use of the natural …

Metastasis accounts for the vast majority of cancer deaths. The unique challenges for
treating metastases include their small size, high multiplicity and dispersion to diverse organ …

The intricate and delicate anatomy of the brain poses significant challenges for the treatment
of cerebrovascular and neurodegenerative diseases. Thus, precise local drug delivery in …

Postsurgical treatment of glioblastoma multiforme (GBM) by systemic chemotherapy and
radiotherapy is often inefficient. Tumor cells infiltrating deeply into the brain parenchyma are …

The unique cancer-associated immunosuppression in brain, combined with a paucity of
infiltrating T cells, contributes to the low response rate and poor treatment outcomes of T cell …

This review summarizes articles that have been reported in literature on liposome-based
strategies for effective drug delivery across the blood–brain barrier. Due to their unique …

This study explored the possibility of utilizing iron oxide nanoparticles as a drug delivery
vehicle for minimally invasive, MRI-monitored magnetic targeting of brain tumors. In vitro …

The ubiquitin–proteasome system (UPS) and ubiquitin-like protein (UBL) conjugation
pathways are integral to cellular protein homeostasis. The growing recognition of the …