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Metabolic engineering: methodologies and applications
Metabolic engineering aims to improve the production of economically valuable molecules
through the genetic manipulation of microbial metabolism. While the discipline is a little over …
through the genetic manipulation of microbial metabolism. While the discipline is a little over …
Pyro-phototronic effect: An effective route toward self-powered photodetection
The Photodetector (PD) refers to an energy harvesting device that can directly convert light
energy into electric current. Such a device has been widely used in different applications …
energy into electric current. Such a device has been widely used in different applications …
Engineering cofactor supply and recycling to drive phenolic acid biosynthesis in yeast
R Chen, J Gao, W Yu, X Chen, X Zhai, Y Chen… - Nature Chemical …, 2022 - nature.com
Advances in synthetic biology enable microbial hosts to synthesize valuable natural
products in an efficient, cost-competitive and safe manner. However, current engineering …
products in an efficient, cost-competitive and safe manner. However, current engineering …
Reconstructing organisms in silico: genome-scale models and their emerging applications
Escherichia coli is considered to be the best-known microorganism given the large number
of published studies detailing its genes, its genome and the biochemical functions of its …
of published studies detailing its genes, its genome and the biochemical functions of its …
Combining mechanistic and machine learning models for predictive engineering and optimization of tryptophan metabolism
Through advanced mechanistic modeling and the generation of large high-quality datasets,
machine learning is becoming an integral part of understanding and engineering living …
machine learning is becoming an integral part of understanding and engineering living …
Designing microbial cell factories for the production of chemicals
The sustainable production of chemicals from renewable, nonedible biomass has emerged
as an essential alternative to address pressing environmental issues arising from our heavy …
as an essential alternative to address pressing environmental issues arising from our heavy …
De novo biosynthesis of rubusoside and rebaudiosides in engineered yeasts
Y Xu, X Wang, C Zhang, X Zhou, X Xu, L Han… - Nature …, 2022 - nature.com
High-sugar diet causes health problems, many of which can be addressed with the use of
sugar substitutes. Rubusoside and rebaudiosides are interesting molecules, considered the …
sugar substitutes. Rubusoside and rebaudiosides are interesting molecules, considered the …
Rhea, the reaction knowledgebase in 2022
P Bansal, A Morgat, KB Axelsen… - Nucleic acids …, 2022 - academic.oup.com
Abstract Rhea (https://www. rhea-db. org) is an expert-curated knowledgebase of
biochemical reactions based on the chemical ontology ChEBI (Chemical Entities of …
biochemical reactions based on the chemical ontology ChEBI (Chemical Entities of …
An atlas of human metabolism
Genome-scale metabolic models (GEMs) are valuable tools to study metabolism and
provide a scaffold for the integrative analysis of omics data. Researchers have developed …
provide a scaffold for the integrative analysis of omics data. Researchers have developed …
Recent advances in systems and synthetic biology approaches for develo** novel cell-factories in non-conventional yeasts
Microbial bioproduction of chemicals, proteins, and primary metabolites from cheap carbon
sources is currently an advancing area in industrial research. The model yeast …
sources is currently an advancing area in industrial research. The model yeast …