Epithelial to mesenchymal transition (EMT) is a well-defined cellular process that was
discovered in chicken embryos and described as “epithelial to mesenchymal …

Metastasis is a significant health issue. The standard mode of care is combination of
chemotherapy and targeted therapeutics but the 5-year survival rate remains low …

Tumorigenesis and progression of cancer are complex processes which transformed cells
and stromal cells interact and co-evolve. Intrinsic and extrinsic factors cause the mutations of …

Structural alterations during epithelial-to-mesenchymal transition (EMT) pose a substantial
challenge to the mechanical response of cells and are supposed to be key parameters for …

Castrate-resistant prostate cancer (CRPC) is the fatal form of prostate cancer. Although
reactivation of androgen receptor (AR) occurs following androgen deprivation, the precise …

Associations between plasma membrane blebbing and metastatic progression have been
widely reported. There are also reports of increased extracellular vesicle (EV) release from …

Highly metastatic prostate cancer cells flowing through a microfluidic channel form plasma
membrane blebs: they form 27% more than normal cells and have a lower stiffness (about …

Cancer will remain a global major health problem unless new diagnostic, prognostic, and
management approaches are discovered to address both loss of life and quality of life. Here …

Communication is key to any process involving the transmission of information or some sort
of signal. For communication to occur, a signal must be created that can be detected. Cells …

Nearly 40,000 new cases of head and neck squamous cell carcinoma (HNSCC) are
annually diagnosed in the United States. The current standard of care for HNSCC patients …