The physiological roles of tau and Aβ: implications for Alzheimer's disease pathology and therapeutics
Tau and amyloid beta (Aβ) are the prime suspects for driving pathology in Alzheimer's
disease (AD) and, as such, have become the focus of therapeutic development. Recent …
disease (AD) and, as such, have become the focus of therapeutic development. Recent …
The essential elements of Alzheimer's disease
Treatments for Alzheimer's disease (AD) directed against the prominent amyloid plaque
neuropathology are yet to be proved effective despite many phase 3 clinical trials. There are …
neuropathology are yet to be proved effective despite many phase 3 clinical trials. There are …
Thrombin induces ACSL4-dependent ferroptosis during cerebral ischemia/reperfusion
Q Tuo, Y Liu, Z ** how we study and target Tauopathies
Converging evidence continues to point towards Tau aggregation and pathology formation
as central events in the pathogenesis of Alzheimer's disease and other Tauopathies …
as central events in the pathogenesis of Alzheimer's disease and other Tauopathies …
Tau-mediated iron export prevents ferroptotic damage after ischemic stroke
Functional failure of tau contributes to age-dependent, iron-mediated neurotoxicity, and as
iron accumulates in ischemic stroke tissue, we hypothesized that tau failure may exaggerate …
iron accumulates in ischemic stroke tissue, we hypothesized that tau failure may exaggerate …
Striking while the iron is hot: Iron metabolism and ferroptosis in neurodegeneration
Perturbations in iron homeostasis and iron accumulation feature in several
neurodegenerative disorders including Alzheimer's disease (AD), Parkinson's disease (PD) …
neurodegenerative disorders including Alzheimer's disease (AD), Parkinson's disease (PD) …
Tau in physiology and pathology
Y Wang, E Mandelkow - Nature reviews neuroscience, 2016 - nature.com
Tau is a microtubule-associated protein that has a role in stabilizing neuronal microtubules
and thus in promoting axonal outgrowth. Structurally, tau is a natively unfolded protein, is …
and thus in promoting axonal outgrowth. Structurally, tau is a natively unfolded protein, is …
Iron neurochemistry in Alzheimer's disease and Parkinson's disease: targets for therapeutics
Brain iron homeostasis is increasingly recognized as a potential target for the development
of drug therapies for aging‐related disorders. Dysregulation of iron metabolism associated …
of drug therapies for aging‐related disorders. Dysregulation of iron metabolism associated …
Tau protein interaction partners and their roles in Alzheimer's disease and other tauopathies
J Sinsky, K Pichlerova, J Hanes - International journal of molecular …, 2021 - mdpi.com
Tau protein plays a critical role in the assembly, stabilization, and modulation of
microtubules, which are important for the normal function of neurons and the brain. In …
microtubules, which are important for the normal function of neurons and the brain. In …
Iron, ferroptosis, and ischemic stroke
Over 30 million people suffer from the consequences of ischemic stroke. The precise
molecular mechanism of neuronal damage during ischemic stroke remains unclear; …
molecular mechanism of neuronal damage during ischemic stroke remains unclear; …